Time will depend how much pain you're in from the tat, but it took 10h with two of us on 100mm HTs and an early crash (over the bars after a mistimed bunnyhop over a water bar N of Holme Chapel) resulting in having to go very slowly the rest of the way – we'd probably have abandoned if the weather hadn't been in our favour.
I reckon it could be done faster with a group of 3-4+ (so you could get a good gate routine going). I believe the course record (IIRC on a carbon Zaskar, during the Pendle Mountain Rescue fundraiser when all the gates are marshalled) is about 4h30.
Aside from some horrible bits (namely the bit to the East of the canal at Bottomley, which can be bypassed by going along the towpath & then picking up the Bridleway S at the Summit pub) it's all fairly fast going.
The answer to what tyres is Panaracer Fire XC Pro USTs.
Andy