Firstly – try it and see. I mean what could go wrong.
Secondly – I doubt it will work well because if a thorn say punctures the tyre and tube, it will be held by the tyre (ie not the tube) and as the tyre and tube move slightly against each other with each rotation, the seal on the tube would be constantly moved/rubbed/broken. Slime gets mixed reviews and that is a much more viscous fluid, so Stan’s and the like probably ain’t going to do it.
Thirdly – see the first point. I’m often wrong.
EDIT – I may have been beaten to a sensible reply – is that using inner tubes or tubeless though Scruff?