Mono M4/Mini here in 200mm/180mm. Piece of cake to bleed and provide plenty of power but my rear Mini has been a bit of a PITA. I'm on my second set of pistons and they don't retract as well as I'd like, result is lots of squealing and pad wear. I also don't seem to be able to get rid of a bit of lever wobble, which isn't really the end of the world.
Experienced quite bad brake fade and loss of power due to over heating a couple of times but that's been on very long downhills on the road, constantly on the brakes at about 30mph for 3 or 4 miles, fully laden with panniers. Never had a problem off road though and I weigh about 16 stone.