Le Guin’s classic stuff pre-1980 is exceptional, landmark work. Another female pioneer of SF is James Tiptree Jr – pen name of Alice Sheldon. Excelled in the short story format.
CJ Cherryh also great, as mentioned – very people driven stories that could be set in any genre really.
Julian May (a woman) has put out some good page turners – along the lines of Anne McAffrey. Lightweight but fun to read.
Connie Willis is well regarded, wins a lot of awards, but I find her stuff dull myself.