Copper Dragon Brewery in Skipton do tours. Set up by an engineer who worked at Rolls Royce and a bit different.
They’ve got an onsite bar and a really good brasserie. You can book tours online too.
If it is an option, you should phone up and double check that, because they recently moved, downsized and now call themselves Grey Hawk Brewery.
Struggling a bit on other stuff, Worth valley railway, Riddlesden Hall is the only NT house I can think of between your two points, malham cove will kill a few hours, Hebden Bridge OKish, Howarth OKish, Skipton (castle/canal) OKish, Bolton Abbey OK, Brimham Rocks OK, Grassington OKish, Kilnsey trout farm always seems quite busy, falconry centre at Settle was ok for young kids.