Plenty of roadies swap pedals all the time, anyone with Favero or Garmin power meters, anyone who rides track on a hired bike. The hire bikes at velodromes will be getting the pedals changed every time they’re ridden as most places ask you to bring your own pedals.
I used to keep my bike in my room under the bed with the pedals off at uni because the shed’s weren’t all that great. Meant the pedals came on/off every ride.
My Look Keo road pedals….no way would I even contemplate doing this.
Why?
It will wear the crank threads (not the pedals) prematurely
I’m entirely unconvinced.
a) it’s a fairly big coarse thread.
b) you use lube, otherwise it just creaks all the time.
c) Precession, the cyclical action of pedaling is constantly moving the threads sufficiently that if they weren’t left/right handed they would loosen and fall out. The movement and force involved in that is far higher than nipping up the pedals with a 5 or 6 mm hex hey.
d) see above, the real world example of hire bikes at velodromes, they probably get the pedals swapped multiple times a day.
cross threading
Only if you’re ham fisted.