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That Novovax news does look promising.
Apologies as I suspect this question has been posed a few times... but...
The 'raw materials' for vaccines, how stressed is the supply side of that part of the manufacturing process?
Also, Great Barrington declaration, WTF is that still doing the rounds?
Oh, and Valveva. Does anyone know if they're likely to be looking for volunteers in the next couple of months?
Or any others tbh.
Edit, I'll just Google vaccine volunteers in the meantime
@FFJA the Oxford trial offered unblinding to volunteers at the point that they were offered an nhs vaccine. In order to not be disadvantaged by volunteering. I’d expect other trials to do the same.
Once again, thank you for this thread.
Back in March, I spent a lot of time searching the internet for information and getting all sorts of conflicting results. Over that time I have found myself googling less, instead, listening to the useful podcasts posted on here and soaking up the science based evidence.
To stay sane during this pandemic, someone like me with a poor education, (my own fault) has had to choose to 'hang their hat' somewhere. Thankfully for me I chose this thread. Lots of other people weren't so lucky and have 'hung their hats' somewhere else, so their information is a lot less factual.
My other half is on the Novavax trial and was told at her appointment this week that once the interim results were published they would be un-blinded and those on the placebo offered the vaccine and the booster 4 weeks after that
Some might find this interesting
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00183-5/fulltext
Headline;
Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence
Not so much in South Africa though… Not safe until we are all safe and all that.
I'd say the opposite, good news for the likes of south africa and their variant, the Novavax has been tested against our own variant in trials, and responded well by the looks of it, so should give their government hope.
Wee question on these variants for folks, do they evolve in areas where the virus is rampant? Or is that cause of the rampant spread? SE England, Manaus, SA, California, all areas with high levels, all have more transmissible variants emerging.
If so, it reinforces the point @seosamh77 made in his post, we should be looking to vaccinated our vulnerable groups then move on to the rest of the planet, otherwise we become some kind of leper island with no one leaving or coming in?.
@docrobster thanks for that. I’ve been seconded with work to a vaccine hub to make cups of tea so I may give them a call as I don’t want to take a left over dose that could more usefully go to someone else.
The lancet paper is interesting and worrying. I hope they can get the extra data to identify which of the factors are driving it
Well I can't say this was a surprise...
BBC News - Covid: Data shows outbreaks in England's offices in lockdown
https://www.bbc.co.uk/news/uk-55843506
Nor the stats on here - MrsMC is a frontline social worker and got her first jab last Wednesday, after 10 months relying on a mask, hand gel, and people's vague grasp of what 2 metres is, including having to take a DV family for emergency medical exams in our car when the Police refused as it failed their risk assessment.
BBC News - Covid: Are teachers more at risk of dying?
https://www.bbc.co.uk/news/55841748
I’d say the opposite, good news for the likes of south africa and their variant
6% of the SA participants had HIV, when these were removed from the analysis, efficacy rose from 49% to 60% (1.3 times more likely not to work if HIV +ve). That's the same as the OX/AZ efficacy against a strain that presents a significant challenge. This is good news. It will never be a one-shot-and-done measles jab, but the time between vaccine changes (annual for influenza) is something that needs time to settle down as the virus becomes seasonal and endemic. That will take a few years.
Seriously, this is very good news for the first non-genetic (i.e., traditional) vaccine platform. The single shot J&J vaccine should read out next week.
Thanks FFJA You're a star.
My NHS nursing friend had her jab on Tues and was ill for about 24 hours, feeling a much better now. She also had C19 a year ago and still has the anti-bodies.
I think it was mentioned earlier that this seemed to be common, or was it dismissed as coincidence (that people who had had the virus got ill after their vaccination).
A neighbour's sister in law also quite ill after her jab, however I don't know if she had C19 or not.
My Missus has perked up today after her bad vaccination reaction. We're 90% sure she had Covid last Spring (not tested but colleagues were positive). Again, only anecdote.
OT in a way but interesting development in the EU/AZ dispute.
Council President Charles Michel has now outlined the legal possibilities for releasing the licences by means of Article 122. Article 122 can help us to take full advantage of market opportunities in vaccine production. The Corona crisis is justification enough to use this emergency article in the EU Treaty. Europe must now do all it can to expand vaccine production. AstraZeneca's vaccine can be produced by many other companies. We should make full use of global production capacities so that a vaccine can be made available to everyone in the world quickly. Indian producers, for example, have already offered to support production on several occasions. AstraZeneca should be generously compensated so that the vaccine can be transferred into the public domain and produced with all the forces of the market.
One of the conditions in the Oxford/Gates/AZ alliance was not for profit until later so generous compensation seems a bit extravagant but then its other people's money they are spending.
I seem to remember UVdL having form with contracts going pear shaped when she was defense minister in Germany. I think she got the EU gig to get her out of the way.
That is all just noise.
By the time the other companies are fully up and running (with approved production) we would be in aug or sept anyway i suspect. The vaccine has been licensed to a while load of places round the world anyway so what the EU think it would achieve other than a political statement i have no idea, it wouldn't change the current vaccine shortages anyway.
As tired said many pages back there is a limit on total global vaccine production anyway from a facilities and capacity stand point.
The EU have published a heavily redacted version of the AZ Vaccine contract:
Section 5 - Manufacturing & Supply, seems to support what AZ have been saying from the outset:
"5.1 AZ shall use its Best Reasonable Efforts to manufacture the Initial Europe Doses within the EU for distribution, and to deliver to the European Hubs after EU Marketing Authorisation"
The contract drafting is pretty poor on several counts:
- it's arguable that the manufacturing doesn't need to commence until AFTER the marketing authorisation - which to date has still not been given.
- the commencement date for manufacturing isn't specifically addressed
The contract does also refer to production sites in the UK but again, because 5.1 is poorly drafted the intent on either side isn't crystal clear.
In any event, AZ can legitimately say that "best and reasonable efforts" when their existing production capacity is completely utilised effectively allows them to deliver little or no finished goods until such time as there is capacity to make doses for the EU.
That is all just noise.
This!
I have huge sympathy for AZ here. Making stuff in BiotechLand is hard. My colleagues on the teams I work on tell us this all the time. But they come through and are largely taken for granted. On these unprecedented timescales nothing should be taken for granted. Do people not believe that everyone is making their "best and reasonable efforts". In every company? In all disciplines? And the regulators everywhere are doing the same, btw. The amount of interaction and advice they are delivering is also unprecedented.
I've just scanned the (indeed heavily redacted) contract and whilst it would clearly be helpful to see the UK one in order to get the full picture, on first read the EU's claims seem to be something of a stretch.
As above, there is no specific timeline for delivery of the "Initial Europe Doses" and in any event these are to be manufactured within the EU (whereas the vast majority of the UK ones are manufactured in the UK). The contract does explicitly envisage a situation whereby AZ is "unable to deliver on its intention to manufacture the Initial Europe Doses and/or Optional Doses under this Agreement in the EU" but the contractual resolution is not to divert from elsewhere but for the EU to make other potential manufacturing sites available to AZ.
I cant help but think the noise from the EU is intended for domestic politics as much as anything else.
I cant help but think the noise from the EU is intended for domestic politics as much as anything else.
I think so. They have a population which is watching other countries getting into double digit percentages of population vaccinated and starting to get highly miffed about it. Why not blame AZ, and by association, us? I'm sure our government wouldn't hesitate to do the same.
I have huge sympathy for AZ here.
AZ only got the license after Bill Gates intervened with Oxford.
The original intention was to make the vaccine available for production by anyone anywhere.
Looks like grandstanding from the EU. No doubt they would look to get some of the UK-bound vaccines through arbitration.
I cant help but think the noise from the EU is intended for domestic politics as much as anything else.
Yes. The media from their own member states have called them out, so now the are using the Brexit strategy to divert attention from their cock up(or own risk management strategy). Somewhat ironic.
Mariner - do you have any more reputable sources for that instead of some obscure South florida website?
Watch the BBC documentary that was in about the Oxford development, they explained why they chose az
I cant help but think the noise from the EU is intended for domestic politics as much as anything else.
Sadly the RW press over here is also using it to grandstand to its audience. Sad to see the vaccine issues being weaponised on both sides.
Someone on legal twitter has just pointed out the EU deal has a Force Majeure clause which includes epidemics as a reason not to be liable for delays. Not so clever.
I'm with TiRed on this. Biologicals supply chains have a whole bunch of variables in play (quality, batch yield, consistency of batch yield and specific issues relating to small variations in equipment on similar lines) that typically take a long time to resolve. It typically takes anywhere from 9-18 months to optimise the end to end process to address these factors.
In this case AZ have achieved something at incredible pace.
They have been altruistic in their approach from the outset - their costs are open book, they've volunteered to take no profit and arguably could have sat back and kept their lines running to churn out something profitable.
It's absolutely appalling to see the way the Oxford / AZ partnership has been used as a political football by Brussels, inferring AZ's CEO has lied, AZ has been dishonest, AZ has reneged on binding commitments etc etc but I suppose it shouldn't surprise anyone - the Commission did the same with Brexit.
Hopefully this thing will go away sharpish once member states apply their own pressure.
The focus should be doing everything possible to support bringing all of the successful vaccine candidates to market - and ensuring we massively ramp up supply to the developed world. For its part, the UK looks like it will be donating 200m+ doses to other countries based on the positions we hold and the commitments made by government ministers.
I think we've also donated more to the global funding pool that any other country (or at least it was reported as such on the radio yesterday) so perhaps the EU could focus on that a bit as well.
EU do look to be shaky ground, looks like they had clauses they thought covered them
But will it end up in a Belgian court
?
https://twitter.com/GreatStrides65/status/1355122772763176960?s=19
AZ do add a warranty at the end to say they don't have any convicting orders for initial doses, which doesn't help their case & can see why EU might think they are being shafted
https://twitter.com/OSchonrock/status/1355122749354733569?s=19
In this climate, how would conflict be defined and such clause enforced? Given that AZ are producing as much as they can, do they expect all production to go to EU?. What is their endgame other than stirring up shit?
So Janssen single does comes in at 66% - how does that compare to a single dose of any of the others?
In this climate, how would conflict be defined and such clause enforced? Given that AZ are producing as much as they can, do they expect all production to go to EU?. What is their endgame other than stirring up shit?
Partly arse covering, but partly getting AZ to send more vaccine, including from UK as contract includes UK in EU vaccine source & says there's no other conflicts....
Be interesting to know if UK gov aware UK sites classed as EU manufacturing
UvDL does seem to be clutching at straws a bit. Allegedly her quote is that the "best intentions" bit only really applied when AZ weren't sure if they would even be able to create a vaccine. Now that they have created one that clause no longer has that meaning and they are due all the vaccines they want and AZ better pick it up. Yet the vaccine still isn't approved for use in the EU yet so not even sure what point she is trying to make
AZ do add a warranty at the end to say they don’t have any convicting orders for initial doses, which doesn’t help their case & can see why EU might think they are being shafted
It doesn't impact it at all, the Initial European Doses are clearly those from the EU factories -see 5.1. - UK factories not included. UK factories only included in 5.4 which is dealing with the wish for the vaccines generally (not just the intial ones) to be manufactured in the EU and UK.
Essentially the contract envisages the possibility of vaccines coming from the UK, but only commits the production from the EU plants, which is what AZ has been saying all along.
Sounds like a very complex dispute to resolve in courts, not just the contracts but in light of the material considerations that constitute the context.
It wouldn't seem reasonable, prima facie, that the EU get an iron-clad guarantee of vaccines vis a vis the UK who ordered first.
By the time it goes through the courts the pandemic will be over with!
I never wanted to leave the eu, but since they played hardball to ensure we got the minimum acceptable deal going, I think it's slightly ironic that the shoe is now well and truly on other foot
Personally, if we are going to give out stocks away, id rather it goes to a developing nation, rather than the eu which has a problem largely of its own making.
I would say mistaken, I think in the rush to report people have misread clause 5.4 as altering the definition of EU for the whole of the clause rather than just the sub clause.
how does that compare to a single dose of any of the others?
It says that they'll likely be testing a two-dose regimen. Response is the same as OX/AZ two standard doses, but a wider population. It's good enough to use and could be made better. That's positive. Only Merck has really thrown in the towel so far (The Queensland vaccine was a non-starter due to HIV test interference).
Extra confusing as further down 5.4 lumps in initial & additional doses
As being made in EU, which for terms of 5.4 includes UK
I'm completely with mefty on this one. What the EU is claiming AZ have failed to do (or, to be accurate given the AZ vaccine hasn't actually even been approved by the EU yet) probably will fail to do is to deliver the "Initial Europe Doses" (and even that is a stretch given the lack of prescribed timescales). However that requirement sits in 5.1 and that is limited to production in the EU. 5.4 gives AZ the ability, subject to certain constraints, to source from other parts of the world with no constraints on AZ if it wishes to source from the UK.
It is not confusing they just want the vaccine made in Western Europe. And if AZ cant manage that there is provision for someone to be found.
Well ianal, obvs!
EMA recommends COVID-19 Vaccine AstraZeneca for authorisation in the EU
including for over 55s
"However, protection is expected, given that an immune response is seen in this age group and based on experience with other vaccines; as there is reliable information on safety in this population, EMA’s scientific experts considered that the vaccine can be used in older adults."
By the time it goes through the courts the pandemic will be over with!
Not so sure about that. Numerous experts/scientists suggesting Coronavirus will be with us for a good while yet with annual jabs as variants spring up over years. What will matter then is the ability to annually produce 00's millions of various vaccines in response to those changes. On this occasion the UK has proven to be smart and nimble, but in the longer term the EU manufacturing prowess will get right on top of it and the best place for the UK to be then is bezzie mates so we can pull together.
Must feel for AZ with the hammering it's getting for the superb efforts it has made in the massive scaling up of a not for profit drug.
Very pleasant surprise to see senior UK politicians managing to moderate their language when referring to the challenges faced by the EU. Hopefully it is recognition the UK needs to work with the EU in the future on health, security, trade, etc ... 🤞
The more I read 5.4 the more I think that section was geared towards worldwide excess production capacity of a vaccine. Which is the situation the EU thought they were going to be in, an excess of suppliers to pick from.
The VMIC scale of production will hopefully kick in soon too. It will at least help hopefully in 2022 and beyond for new strains
This could get messy, before it gets sorted…
https://twitter.com/faisalislam/status/1355192363522658309?s=21
Today's death stats are late again 🤔
I'm sure the last time they did that it was VERY high. 😱
I do hope this isn't repeated endlessly if new strains emerge that make vaccines less effective
IIRC 39m vaccine doses govern worldwide, but all in richest countries
Only poor country is Guinea which has received 25 doses from Russia
Aside from gross inequality
That's a huge infection pool for new strains to emerge from
I’m sure the last time they did that it was VERY high
Sadly it's pretty much guaranteed that death rates aren't going to be getting better for another week or so - the number of people in hospital has only just stopped growing and JVT said that we're now at about 20% mortality for that group, so with 38K in hospital that's 7.6K deaths already 'in the system'. 🙁
A single-dose coronavirus vaccine developed by Janssen is 66% effective, the Belgian company has announced.
EDIT: apparently 85% effective against serious disease, and 100% effective against hospitalisation and death in trials.
https://www.bbc.co.uk/news/health-55857530
Great news for wider cheaper distribution.
The fact it works as a single dose and can be kept in a standard fridge, while others need super-cold storage, means the vaccine could have a significant role around the world.
Only poor country is Guinea which has received 25 doses from Russia
Aside from gross inequality
I think I read that Russia has given 10000 doses to the Palestinians. Obviously it would have been sensible for the Israelis to include Palestinians in their programme but of course that was a non-starter.
How much of the ingredients and requisite specialist factory/manufacturing is shared between the different vaccines?
Something must be critical path / limiting production speed, at what point do the various competing vaccines and the interests of the companines making them become detrimental to the overall aim of getting the most number of vaccines in peoples arms?
The more I read about this matter of the EU's procurement of vaccines (specifically the AstraZeneca one) the more I'm convinced that the commission is just trying to save face for being too slow and risk-averse.
I agree, I'm beginning to think this actually could be an existential threat to the eu, between the vaccines and the recovery plan.
If they get it wrong then a lot of people will be wondering what's the point. This is said as someone who wants to be in the eu, but the behaviour here has been atrocious.
I think bojo should say he is willing for a proportion of the UK allocated production should go to the eu. It won't make a difference to total numbers but the European commission will wear it
Indeed. Vaccine diplomacy?
How much of the ingredients and requisite specialist factory/manufacturing is shared between the different vaccines?
Something must be critical path / limiting production speed, at what point do the various competing vaccines and the interests of the companines making them become detrimental to the overall aim of getting the most number of vaccines in peoples arms?
What has been the challenge is the upscale of the manufacturing to unprecedented levels. The UK plant which was started earlier, ironed these out in advance (there were also delays?), these now need to be ironed out for the EU plant.
I suppose if each country went its own way, a few countries would be getting the vaccines they asked for on time, at the expense of the other nations. I don’t understand why some people think this would be a better outcome as regards handling this pandemic. We need more international cooperation, not less, unless we want to all crawl into our national silos and hide for a few years.
Anyway… all this focus on vaccines is useful for forgetting our current tools for stopping transmission. We need self isolating and contact tracing to work, and for that to happen we need to be support people who need to isolate.
https://www.bmj.com/content/372/bmj.n224
Support for self-isolation is critical in covid-19
(Published 27 January 2021)
Socioeconomically disadvantaged and many ethnic minority groups have been disproportionately affected, with increased risk of infection, hospital admission, and death
Despite the vaccine rollout, many younger people, particularly those working in high exposure occupations, living in overcrowded housing, or without a home will remain subject to an ongoing burden of quarantine orders, along with a disproportionate risk of infection and onward transmission for the foreseeable future. An equitable and effective public health response requires the integration of supportive services to effectively decrease their contact rates and subsequently risk of infection.
…the ability to quarantine until test results are available, and to isolate if positive, depends on people having the space and resources to do so. Survey data from the UK suggest that less than one in five people are able to adhere to isolation protocols. Notably, lower rates of adherence have been reported among men, younger people, key workers, those living with dependent children, and those in lower socioeconomic groups.
Several well described models have been shown to enhance compliance with quarantine and isolation. Fundamental components include ensuring financial security and compensation as well as practical support.
The EU is now in beach of their own contract. The version they published contained all of the metadata for the “redacted” sections. Someone on Reddit has helpfully unredacted all of the sections including the sections on dosing and pricing.
Someone’s also made the point that the force maejure clause contained in the contract essentially says that in a pandemic all bets are off. 🙄🤣
Got a link to the unredacted one?
The EU is now in beach of their own contract. The version they published contained all of the metadata for the “redacted” sections. Someone on Reddit has helpfully unredacted all of the sections including the sections on dosing and pricing.
They shouldn't even be publishing 'redacted' parts of the contract. Disgraceful behaviour from the EU.
Not that exciting really…
Just the start of subheadings or first line of copy in sections.
Very little of the redacted content can be retrieve from the metadata. So we’re still pretty much in the dark. And without seeing the UK contract, we still have no idea if AZ are doing anything odd at all (I doubt they are, as it happens).
Someone on Reddit has helpfully unredacted all of the sections including the sections on dosing and pricing.
So… not this.
Clip from Indy Sage about actually making schools (and elsewhere) safe…
https://twitter.com/independentsage/status/1355202661574987783?s=21
I think I read that Russia has given 10000 doses to the Palestinians. Obviously it would have been sensible for the Israelis to include Palestinians in their programme but of course that was a non-starter.
Just the usual from the Israelis. 😔
I think what this has really highlighted is the self-serving power hungry slow turning bureaucracy of the EU commission. They've been caught with their pants down, and rather than admit they've been wrong, they're now desperately flinging mud in the hope some will stick somewhere to not make themselves look bad.
The NI thing just shouts desperation. As somebody highlighted, all it's going to do is cause political friction for no gain on their part. The UK will have the most vaccine options and production capacity, so if they want a tit for tat vaccine export battle, the EU doesn't have the better hand at the moment.
All the UK government has to do, is ensure our own contracts are met, leave the pharma companies to do their job, and export the additional production to whoever they see fit.
Something I have been surprised to learn, is the UK has been the biggest funder for the various worldwide vaccine programs, whereas the EU has invested very little.
Then there is this graphic that has been doing the rounds-
The EU are really not looking good over this. Looks like they want everybody else's cakes and to eat them, because they spend three extra months negotiating and didn't even buy their own cake mix or turn the oven on.
I'd also like to see the figures behind the money they 'gave' to help development and production, which the pharma companies are saying they never actually received.
The UK gave the money upfront, in return for vaccines should they become available, and not just allocate a budget and send an IOU. This is something the UK government did get right, and which we are now seeing the major benefits off.
Something I have been surprised to learn, is the UK has been the biggest funder for the various worldwide vaccine programs, whereas the EU has invested very little.
https://ec.europa.eu/commission/presscorner/detail/en/ip_20_2262
Team Europe contributes €500 million to COVAX initiative to provide one billion COVID-19 vaccine doses for low and middle income countries
And then…
Then there is this graphic that has been doing the rounds
Could you link to the source of that data please? I’d be interested if it includes funding that nation states have provided for development.
For example this, which directly benefited many old people we know back here in the UK early on…
The truth is that Pfizer didn’t receive any funding from Operation Warp Speed for the development, clinical trial and manufacturing of the vaccine. Rather, its partner, BioNTech SE, has received money — from the German government.
Berlin gave the German company $445 million in an agreement in September…
https://fortune.com/2020/11/09/pfizer-vaccine-funding-warp-speed-germany/
I’d say the opposite, good news for the likes of south africa and their variant
...
Seriously, this is very good news for the first non-genetic (i.e., traditional) vaccine platform. The single shot J&J vaccine should read out next week.
Thanks TiReD and NoBeer for the 'glass-half-full' perspective on this. Without trying to diminish the importance of what has been achieved, I guess it worries me that variants that arose prior to any vaccine-related selection pressures have a decent level of escape - we really need to reduce the infection level everywhere AND vaccinate the world fast to avoid creating a perfect breeding ground for vaccine-resistant strains.
From what I can make out the whole argument centres around wher the vaccines are made and where they end up being used.
We had an advantage by being the first to clear the vaccine for use so all the UK capacity went into our initial stockpile ready for the rollout. Now that we are using up that stock all the UK factory's production is going to us. All good so far. The EU order what's to do the same, build a stockpile then hit the ground running, but the delays from the EU factories have scuppered that plan. The EU are now looking at the contract they gave where the EU-made vaccines go to them but it looks like some of the stick that was made before now has been coming to us and they want an equivalent stock back from the UK factory. This is not happening so we now have a standoff with export controls and legal fights.
Can't help but think that this could all have been avoided somehow. The obvious thing would be if Brexit hadn't happened or we had joined the EU vaccine scheme but then you have the issue of we seem to have managed to come out of this little issue actually ahead. The fact remains though that even if we 100% vaccinate all of the UK population we still run the risk of importing new strains from countries that are still vaccinating. This means we'll be stuck at home unt everyone catches up. Surely this is one of those times where looking at the world picture rather than inward at ourselves is the correct choice?
Interesting article on the money put in for manufacturing scale up and other factors.
guardian link
This is not happening so we now have a standoff with export controls and legal fights.
The EU are just expelling hot air and sabre rattling to try and ensure supply through political pressure… there is nothing for them to do legally really, is there. Politics at its worst. Disgraceful really. It is prompting a lot of fake news spreading amongst Brits though. We’re ripe for it, aren’t we.
I asked to be unblinded from the Novavax trial to avoid having a second vaccine but they wouldn’t let me, said the sponsors protocol is still for it to remain blinded. Pretty frustrating tbh.
You will find more infographics at Statista
I was actually looking for something else. Not sure what I expected but didn’t expect that volume of vaccine coming out of the U.K.
I'm surprised at the UK levels in that chart.
That's cool. I wonder what current production levels are.
My parents (both over 80) were also on the Novavax trial, but were unblinded as soon as they were offered the Pfizer vaccine. They have been asked to carry on follow up appointments to monitor their blood, which they have agreed to do.
One can only assume that they will unblind you once you are eligible for an already approved vaccine, or will be offered the Novavax as soon as it becomes licenced, whichever comes first.
If you have a vaccination booking i am sure they will unblind you quickly. All trial protocols will have the triggers for that built in and am sure they will have considered receiving a licensed vaccine.
Wait until you get an appt then contact the investigator at your trial site, and if no joy there (which i would be surprised at) then ask to contact the site monitor.
Not sure what I expected but didn’t expect that volume of vaccine coming out of the U.K.
We’ve been preparing for the ramp up for a year now. There are two members of this forum involved. Perhaps they’ll fill us in on the numbers being aimed for, and the state of play on site. It’s all looking very positive.
Why isn’t Belgium on that chart though?
Surely this is one of those times where looking at the world picture rather than inward at ourselves is the correct choice?
If we manage to get the UK vaccinated ahead of the rest of the world I'm more than happy that we stay at home and keep quarantine in place for arrivals until they manage to catch us up.
@Vazaha, yeah, I’ve emailed them again as I’m being offered another approved vaccine through work. Quite happy to keep all the follow up blood tests etc. Which were your parents on?