Forum menu
The Coronavirus Dis...
 

The Coronavirus Discussion Thread.

Posts: 31075
Free Member
 

Eiré

Where now?


 
Posted : 12/07/2020 11:16 am
Posts: 34971
Full Member
 

I doubt many on here give much of a rat’s ass about anyone knowing they’ve been for a pint, I know I don’t.

But you can imagine people for whom that would be an issues though, right?

Plus nobody would know where I’ve been by looking at my phone’s location, ‘cos I use a VPN and I don’t use Google or Fb, LinkedIn, WhatsApp, Instagram…

The idea that if they wanted to this Govt (or any other for that matter) couldn't track you via your phone whenever they felt like it is going to be defeated because you don't use a popular social media channel is flat earth thinking, frankly.


 
Posted : 12/07/2020 11:26 am
Posts: 0
Free Member
 

Plus nobody would know where I’ve been by looking at my phone’s location, ‘cos I use a VPN and I don’t use Google or Fb, LinkedIn, WhatsApp, Instagram…

Oh noes, I use Google, Facebook and Whatsapp.

Is Boris in my attic drilling holes and peeking at me?

Ffs get a grip, no one cares where you've been, unless you've been a naughty boy.


 
Posted : 12/07/2020 8:13 pm
 kilo
Posts: 6904
Free Member
 

Ffs get a grip, no one cares where you’ve been, unless you’ve been a naughty boy.

You don’t really get the security aspects of vpn do you?


 
Posted : 12/07/2020 8:40 pm
Posts: 8296
Free Member
 

Not sure why anyone would think they are important enough that the government (or anybody else for that matter) cares where they have been, or what they have been doing. Just comes across as paranoid..

Anyways, I heard there was going to be some news next week about vacine progress..can't imagine it's going to be confirmation that it works based on the fact there's not been enough community transmission to establish that yet..


 
Posted : 12/07/2020 8:50 pm
Posts: 0
Free Member
 

You don’t really get the security aspects of vpn do you?

Did I say anything about the VPN?


 
Posted : 12/07/2020 9:02 pm
Posts: 33076
Full Member
 

I can see why a group of women might not want to give pub staff they don’t know their addresses on bits of paper to keep behind the bar though.

I've not yet been asked for an address for track and trace, but I get the point.

No data system is completely safe. I'm fear that the paranoia on the issue in the UK will hamstring any solution.


 
Posted : 12/07/2020 10:53 pm
Posts: 31036
Full Member
 

It is something that “any solution” needs to overcome, not ignore, if it is to be a solution.


 
Posted : 12/07/2020 11:04 pm
 kilo
Posts: 6904
Free Member
 

Did I say anything about the VPN?

You quoted it in the post followed with your usual sarcy comments, so effectively yes, you did.


 
Posted : 12/07/2020 11:13 pm
 gray
Posts: 1369
Full Member
 

Here's a paper which discusses the possibility of preexisting immunity:

https://www.nature.com/articles/s41577-020-0389-z


 
Posted : 12/07/2020 11:49 pm
Posts: 13349
Full Member
 

I’m fear that the paranoia on the issue in the UK will hamstring any solution.

It's not paranoia, just prudence. The current shower have form for big data abuse and like the environment every little that we can do to thwart the growth of their espionage helps. It is none of their business what we the populace do, unless you are a sociopath who worries that you'll get yours if you don't keep tabs on everything.


 
Posted : 13/07/2020 4:20 pm
 DrJ
Posts: 13939
Full Member
 

Funny, the pub I’ve been to for the last two evenings has laminated cards on all of the tables with a QR code that you can scan, which opens a site where you put in your location, name and a phone number, which seems like a ‘digital solution to me; perhaps my interpretation of ‘digital solution’ is different to yours

This is the official "world beating track and trace system" in action - subcontracted to pub landlords. Likewise the customers at the pub in Batley that was shut down were contacted by the landlord, not by PHE. Maybe this is a subtle way to get us all back in the pub - it's the only way anyone will get tested for Cv ?


 
Posted : 13/07/2020 4:39 pm
Posts: 31036
Full Member
 

To be fair… you can get tested easily now… especially if you can drive.

The track/trace/isolate and app failures are obvious and indefensible, at this late stage. We needed and should have had this fully in place before we relaxed social distancing measures (the government even said so themselves, before they realised their private sector chums weren’t really up to that kind of delivery timeline… to put it mildly).


 
Posted : 13/07/2020 4:46 pm
Posts: 34479
Full Member
 

So masks are not popular with some of Johnson's base....


 
Posted : 14/07/2020 10:44 am
Posts: 5299
Free Member
 

It’s the one thing I genuinely don’t get...

Why is wearing a mask such a huge issue for some?...

I mean it, quite literally, won’t kill you...

Covid on the other hand..


 
Posted : 14/07/2020 10:56 am
Posts: 7094
Free Member
 

So masks are not popular with some of Johnson’s base

Is that a genuine bias in Tory voters?


 
Posted : 14/07/2020 10:58 am
Posts: 33076
Full Member
 

every little that we can do to thwart the growth of their espionage helps

At the expense of public health and safety?

My data has been widely available probably since the internet was invented. No one seems to have abused that knowledge yet.

I genuinely don't see the risk to me. I don't care who knows where I go or who I'm with or what websites I look at. And no one has yet given me a concrete example of it happening to them either.


 
Posted : 14/07/2020 11:16 am
Posts: 1048
Free Member
 

And no one has yet given me a concrete example of it happening to them either.

https://techcrunch.com/2019/11/27/brexit-ad-blitz-data-firm-paid-by-vote-leave-broke-privacy-laws-watchdogs-find/


 
Posted : 14/07/2020 11:28 am
Posts: 0
Free Member
 

You quoted it in the post followed with your usual sarcy comments, so effectively yes, you did.

Oh I'm sorry, should I have quoted it as follows just to make sure you understood it despite me specifically calling out the items I was referring to -

Plus nobody would know where I’ve been by looking at my phone’s location, ‘cos I use a and I don’t use Google or Fb, LinkedIn, WhatsApp, Instagram…

My bad.


 
Posted : 14/07/2020 11:47 am
Posts: 12649
Free Member
 

So masks are not popular with some of Johnson’s base

Because the mask has been sold as a device to protect others so if you don't care about others then why would you want to wear a mask.


 
Posted : 14/07/2020 11:53 am
Posts: 8095
Free Member
 

On a train heading into Leeds at the moment. I'm the only person wearing a mask. No guard on board (well, there is, but he's hiding at the back).

Can't see it working in shops, most people are incapable of following the one way system or social distancing guidelines to begin with.


 
Posted : 14/07/2020 12:10 pm
Posts: 34479
Full Member
 

On a train heading into Leeds at the moment. I’m the only person wearing a mask. No guard on board (well, there is, but he’s hiding at the back).

Can’t see it working in shops, most people are incapable of following the one way system or social distancing guidelines to begin with.

It's about 70% compliance on my train into London

Not enforced at all


 
Posted : 14/07/2020 12:21 pm
Posts: 20616
Full Member
 

Can’t see it working in shops, most people are incapable of following the one way system or social distancing guidelines to begin with.

Nationally, compliance is about 80% overall but with certain spikes of non-compliance.

Wearing it in shops may actually help because the message at the moment is incredibly confusing around stations, on public transport, in shops on stations and so on. Some consistency would help greatly with compliance.


 
Posted : 14/07/2020 12:25 pm
Posts: 0
Free Member
 

Having worked (driven) trains through the lockdown across the north there are definitely certain areas and times when face covering compliance is better than others. Commuters seem pretty good at taking precautions. However a lot of people who wear them seem to think that once they're on the train they can pull their face covering down away from their mouth and nose. In my opinion making them mandatory in shops will have a positive effect on overall carrying of them by the more casual travellers.

Bigger stations like Manchester Piccadilly & Leeds have a lot of staff enforcing walking routes to avoid crowding, giving out face coverings and trying to enforce the unenforceable.

Train use nationally is still between 10 and 20% of normal levels. And I suspect that in the south that figure is a bit higher than in the north. I have to travel on the train as a passenger sometimes to get from A to B while in work, and I have no problem with that at the moment. I'd refuse to get on a packed train but I've not had to be put in that situation yet.

Public transport is still meant to be for essential travel only. Once a train leaves a main station though, out in the wilds there is little that can be done. During the day, random groups of bored kids/adolescents off on a jolly appear every now and then knowing there's not much revenue protection being carried out at smaller intermediate stations. A train I worked out of Blackpool at the weekend was full of the sort of people who I assume haven't seen any news for six months. Mostly families who travelled all the way back towards Manchester. The other evening I saw the guard on my train have to tell four folks who turned up on MTBs at Hebden Bridge that, sorry, they couldn't board. We already had two or three bikes on, the maximum allowed is two even in normal times, and every additional bike can make social distancing more difficult with people having to squeeze past others etc.

There's been the odd incidence of people being assaulted at work, one or two spitting incidents etc., but most of the crime has actually been trespass the on the railway, usually the scourge of the Easter/summer school holidays.

At work we all feared the worst once the pubs opened but the late trains around the north seem to be generally quiet for now.

Our company is still running what can basically be compared to a Sunday service.

It's strange because we know the whole rail industry is on life support and nobody knows how long redundancies will take if passenger numbers don't return in the next year or so. There's certainly nowhere near enough business to fill three Pendolinos per hour between Manchester and Euston. At the moment there is still recruitment and training going on at my firm. All the TOCs are all but nationalised (my own employer was officially taken into public hands a month before the lockdown anyway due to dire performance) but there's no way the passenger train operating companies can revert back to their previous commercial setups, half of them were on the verge of going bust/handing the keys back anyway.


 
Posted : 14/07/2020 1:15 pm
Posts: 34479
Full Member
Posts: 34479
Full Member
 

It’s strange because we know the whole rail industry is on life support and nobody knows how long redundancies will take if passenger numbers don’t return in the next year or so. There’s certainly nowhere near enough business to fill three Pendolinos per hour between Manchester and Euston. At the moment there is still recruitment and training going on at my firm. All the TOCs are all but nationalised (my own employer was officially taken into public hands a month before the lockdown anyway due to dire performance) but there’s no way the passenger train operating companies can revert back to their previous commercial setups, half of them were on the verge of going bust/handing the keys back anyway.

My train from london to MK has gone from 1000 passengers at rush hour (completely rammed, social distancing of about 5cm max) to 100 people max according to social distancing rules & they dont seem to have reached that capacity yet

cant imagine the size of the losses they are making!


 
Posted : 14/07/2020 2:00 pm
 AD
Posts: 1577
Full Member
 

Genuine LOL at the tory activists. You would think they would be tearing up membership cards in shame at the performance of this shoddy government.
Like Cummings will give shit about those useful idiots - after all who else are the going to vote for 🙂


 
Posted : 14/07/2020 2:07 pm
Posts: 0
Free Member
 

And yet we plough on with HS2, which isn't really about high speed rail (it won't even be that quick) but is instead about freeing up paths (capacity) to allow more trains to run on the 'normal' railway which had run out of room.


 
Posted : 14/07/2020 2:09 pm
Posts: 34971
Full Member
 

So masks are not popular with some of Johnson’s base…

I did read somewhere that there's a strong correlation between folks who don't want wearing a mask to be compulsory, but do want to make wearing a poppy compulsory...I think it was meant as satire, but these days it's hard to tell TBH.


 
Posted : 14/07/2020 2:24 pm
 mehr
Posts: 737
Free Member
 

We're about to see a whole other level of stupid about wearing masks.


 
Posted : 14/07/2020 2:38 pm
Posts: 31036
Full Member
 

is instead about freeing up paths (capacity) to allow more trains to run on the ‘normal’ railway which had run out of room

It is indeed. Capacity and demand/use over the next year or so isn't relevant though, HS2 is about future, not current, capacity. It's way off still.


 
Posted : 14/07/2020 2:44 pm
 Del
Posts: 8274
Full Member
 

That Tory up there is fabulous. If anyone who knew him had any doubt at all in their minds that actually, underneath, he might be alright, that doubt has surely been removed now. Lol. ****


 
Posted : 14/07/2020 5:47 pm
Posts: 5820
Full Member
 

I was quite amused by Hancocks reponse to the tory mouth breather going on about a monstrous impostition over using masks for shopping


 
Posted : 14/07/2020 6:28 pm
Posts: 8469
Full Member
 

Bloomberg Article

Link above to today’s article following the Oxford vaccine. An interesting read, and definitely looking promising.


 
Posted : 15/07/2020 1:38 pm
Posts: 13282
Free Member
 

Sounds good. Fingers crossed.


 
Posted : 15/07/2020 2:28 pm
Posts: 8527
Free Member
 

I was quite amused by Hancocks reponse to the tory mouth breather going on about a monstrous impostition over using masks for shopping

Just witnessed 3 generations of a family going into the supermarket and showing some yellow lanyard when challenged about wearing a mask by security, which seemed to allow them the freedom of asda, unmansked.

Irony is the that the mother, her daughter and kids granny were morbidly obese, pretty much the target audience for that wee bugger covid.

Still, 7 days with no deaths now, we must be doing something right.


 
Posted : 15/07/2020 2:43 pm
Posts: 14529
Free Member
 

It's all gone very quiet so I'm bumping this up the page


 
Posted : 16/07/2020 1:04 pm
Posts: 33076
Full Member
 

Rather indicative of how it's dropped down everyone's radar I guess.


 
Posted : 16/07/2020 1:08 pm
Posts: 12649
Free Member
 

I was quite amused by Hancocks reponse to the tory mouth breather going on about a monstrous impostition over using masks for shopping

Ah, Desmond Swayne, my MP in very safe 60-70% seat for last 20 years. He also doesn't mind a bit of blacking up. You would wonder how the hell someone like that gets elected until you talk to people who live in the New Forest...


 
Posted : 16/07/2020 1:31 pm
Posts: 7094
Free Member
 

Rather indicative of how it’s dropped down everyone’s radar I guess.

Yup. It'll be slipping further down the radar, until it's up again.

Meanwhile, I expect the government will be doing an excellent job of preparing our medical resources, staff, and infrastructure for another wave.

Not.


 
Posted : 16/07/2020 1:47 pm
Posts: 7193
Full Member
 

showing some yellow lanyard when challenged about wearing a mask by security, which seemed to allow them the freedom of asda, unmansked.

Sunflowers?

If so, maybe the kids have some sort of neurodiversity, which make mask wearing difficult for them. Maybe the adults have it too.

https://hiddendisabilitiesstore.com/


 
Posted : 16/07/2020 1:52 pm
Posts: 34479
Full Member
 

its OK government are on top of the deets

https://twitter.com/TobyonTV/status/1283673534254977024


 
Posted : 16/07/2020 1:54 pm
Posts: 5820
Full Member
 

Utter moron, we truly live in an idiocracy


 
Posted : 16/07/2020 2:02 pm
Posts: 20616
Full Member
 

Still, 7 days with no deaths now, we must be doing something right.

That's not right, NHS page is still showing a handful of deaths per day and that's just in hospitals, not care homes or the wider community.


 
Posted : 16/07/2020 2:04 pm
Posts: 7128
Free Member
 

Odd source but it's George Davey-Smith:

https://www.workersliberty.org/index.php/story/2020-07-15/socialist-epidemiologist-pandemic


 
Posted : 16/07/2020 2:51 pm
Posts: 31036
Full Member
 

That’s not right

He meant in Scotland... were it does indeed look like they've been doing something right.


 
Posted : 16/07/2020 2:59 pm
Posts: 7801
Free Member
 

Perhaps a different "we".


 
Posted : 16/07/2020 3:08 pm
Posts: 17326
Full Member
 

Rather indicative of how it’s dropped down everyone’s radar I guess.

Not me. Analysis this week has thrown up a few outlier areas, but deaths are in the normal range. Probably because we have traded RTAs for COVID19, and are yet to see cancer deaths increase.

Much debate about immunity and waning antibodies. Some nice data from Pfizer and Moderna on antibody vaccine response in their trials. And the day job.

Cases and deaths look like to stabilise at about 1-200 deaths per week. And then winter is coming...


 
Posted : 16/07/2020 5:20 pm
Posts: 7094
Free Member
 

You're not the average punter TiRed


 
Posted : 16/07/2020 5:23 pm
Posts: 31036
Full Member
Posts: 8296
Free Member
 

I posted a few days ago that there would be an announcement about the Oxford vacine, although i didn't know what it would be.

How did I know...turns out my big bro is part of the team involved in its development. Didn't realise that until my mum told me at the weekend!


 
Posted : 16/07/2020 9:32 pm
Posts: 868
Full Member
 

https://news.sky.com/story/coronavirus-sage-urged-govt-to-lockdown-a-week-earlier-uks-chief-scientific-adviser-says-12029956

The virus was doubling every 3.5 days prior to lockdown, so the weeks delay ignoring Sage allowed the number of infections/deaths to quadruple. Well done Boris.


 
Posted : 16/07/2020 10:31 pm
Posts: 1442
Free Member
 

Some info on why English numbers are different to the rest of U.K.

https://www.cebm.net/covid-19/why-no-one-can-ever-recover-from-covid-19-in-england-a-statistical-anomaly/


 
Posted : 16/07/2020 10:35 pm
Posts: 4710
Free Member
 

So Hancock can call an urgent inquiry when it suits him then. He wants to get the death count reviewed so that it can be lowered!

What about all the other failings?


 
Posted : 17/07/2020 11:33 am
Posts: 33076
Full Member
 

Update in the Guardian suggests a revision in numbers might take a thousand off the total.

Although given what we now know about the longer term effects of the virus, there might be more delayed deaths due to it?


 
Posted : 17/07/2020 11:40 am
Posts: 7614
Full Member
 

Meanwhile in the US:

https://www.theguardian.com/world/2020/jul/17/global-report-us-democrats-urged-to-skip-convention-as-covid-19-cases-surge

The US has seen about 1 million new cases in the last 20 days (no that's not a typo).

Deaths are a lagging indicator but you can assume that around 5% of those infected will go onto to die. If there was any justice then it would only be affecting the "God's Breathing System", "My Body My Choice", #NoMask nutjobs but unfortunately the virus is a bit more indiscriminate.

The US is now working as a cautionary tale for the rest of the world about easing lockdown too early and getting "back to business".


 
Posted : 17/07/2020 12:04 pm
Posts: 31036
Full Member
 

I hope no-one is listening to Johnson's press conference... because he's only seeding more confusion...

You can both get back to your workplaces, and use your elderly at risk parents for childcare... because you can form a two household bubble with those grandparents... that's what he says... but how are you forming a bubble if you're also mixing with two lots of workmates...?

Anyway, he's basically kicked the ball over to employers.. it's over to them.


 
Posted : 17/07/2020 12:39 pm
Posts: 9591
Full Member
 

I've been shopping in the local independent shops, where signage and safety is really good.
In the butchers, there is a thick yellow line, running the length of the counter. Out of the 3 people only allowed in at one time, I'm the only one complying by standing behind it. Arrgghhh. People going the wrong way with arrows, people not social distancing and leaning over, because their shopping needs to be packed quicker.

It's been an education in idiotship over the past few months (also selfishness and inconsideration).


 
Posted : 17/07/2020 3:20 pm
Posts: 3273
Free Member
 

Some info on why English numbers are different to the rest of U.K.

Interesting!

By this PHE definition, no one with COVID in England is allowed to ever recover from their illness. A patient who has tested positive, but successfully treated and discharged from hospital, will still be counted as a COVID death even if they had a heart attack or were run over by a bus three months later.


 
Posted : 17/07/2020 3:27 pm
Posts: 14529
Free Member
 

@Bunnyhop  -  Remember the fuel crisis in 2000? The people who kept queuing to fill their tank after their daily 5 mile commute are more than likely the same arseholes causing problems in the shops, buses, etc. now


 
Posted : 17/07/2020 3:30 pm
Posts: 28593
Free Member
 

By this PHE definition, no one with COVID in England is allowed to ever recover from their illness. A patient who has tested positive, but successfully treated and discharged from hospital, will still be counted as a COVID death even if they had a heart attack or were run over by a bus three months later.

If they have a heart attack/stroke a couple of months after being seriously ill with Covid, there's a fair chance it was contributory. There are people who are struggling with the after-effects of this virus many months later.

And really, truly, does anyone really think this counting method is responsible for a sizeable chunk of the 50-150 deaths we're getting a day?

The truth is we are down to our endemic baseline. Which is much larger than other European countries. It doesn't look good and the government is desperate to magic it away. It's just inconvenient that people are dying partly or wholly because of this virus even months after discharge from hospital.


 
Posted : 17/07/2020 3:53 pm
Posts: 3273
Free Member
 

The truth is we are down to our endemic baseline. Which is much larger than other European countries. It doesn’t look good and the government is desperate to magic it away. It’s just inconvenient that people are dying partly or wholly because of this virus even months after discharge from hospital.

Indeed, I'm not disputing that. Scotland, Wales and Northern Ireland cap it at 28 days so the UK figure needs to be consistent.

If/when we do get a 2nd wave, the death figures might be including people dying in the summer so could be very misleading.


 
Posted : 17/07/2020 4:04 pm
Posts: 31036
Full Member
 

needs to be consistent

Use excess deaths (averaged over a week or so) not daily reported deaths from the virus to get a meaningful figure to compare with other countries... the figures you are looking at are only useful for day to day mitigation planning... they will never be useful for comparison between countries, the data collection will never be consistent in different medical systems.


 
Posted : 17/07/2020 4:27 pm
Posts: 7503
Free Member
 

There's no baseline, it's just not quite taken off again yet. We are right on the edge now, case numbers are up fairly consistently over the past week or so, and it's easier to see it getting worse rather than better IMO. Mind you, I've been too pessimistic before.


 
Posted : 17/07/2020 7:02 pm
Posts: 91159
Free Member
 

I had a look at Spain and Italy on worldometers today, they are starting to climb after having been very low. If we have had more transmission that would give us more population immunity even if it's short term, no? Would we then expect to see a lower second peak?


 
Posted : 17/07/2020 11:24 pm
Posts: 95
Free Member
 

The US has seen about 1 million new cases in the last 20 days (no that’s not a typo).

Deaths are a lagging indicator but you can assume that around 5% of those infected will go onto to die.

Crazy numbers, however IFR is about 0.6% when averaged over all age groups, only gets to 5% for the >65s (and greater for even older). So it is not reasonable to assume that 5% of that 1m people will die if those infections are spread proportionally across age groups (and some evidence that they are concentrated in younger people). But it is a huge reservoir of infection, lets hope they can do better than us and keep it out of care homes...


 
Posted : 18/07/2020 12:08 am
Posts: 2003
Full Member
 

It will be interesting to see how the Southampton saliva test trail goes for early warnings.

Yesterday's briefing was somewhat surreal pushing all back to normal by Christmas. Although I'm going for Remembrance Sunday being the designated day for normal - keeping with the jolly war narrative. It did seem a bit bizarre to push normal the day after worst case scenario warnings. You'd think the government would be re-enforcing the need for maintaining biosecurity.

It's going to be a whole mess of mixed messages with the local / national split. Bojo spouting jingoistic bojisms all over the place whilst local authorities try to get the biosecurity / lock lockdown messages out. I can't see Team Boris resisting taking chapter and verse from the Trump playbook but reading local authorities for states.


 
Posted : 18/07/2020 9:03 am
Posts: 17326
Full Member
 

Was looking over the euro data this morning. We are at low endemic levels for cases. And that holds true for almost every country. Yes that includes Norway and Denmark btw. Deaths do follow cases, and I did an analysis yesterday to predict a 50% probability that we will report zero U.K. deaths On one day before end of August. That assumes things continue to decline. They won’t.

As for Christmas, I said this very early and I’ll say it again, a month is a long time in an epidemic process. Cases are not currently declining, deaths have a half-life of three weeks. Prediction beyond September is futile. The reasonable worst case is just that, an upper bound.


 
Posted : 18/07/2020 2:41 pm
Posts: 5299
Free Member
 

@TiRed

I just want to extend a personal thanks for your posts on this thread.

Unpolitical, comprehensible by a layman yet detailed, thoughtful, concise & thankfully without hyperbole or baggage. It sounds like you’ve your hands full work wise yet you take time to post your thoughts here.

Chapeau.


 
Posted : 18/07/2020 6:58 pm
 DrJ
Posts: 13939
Full Member
 

I is confused. Is this ...

https://www.theguardian.com/uk-news/2020/jul/18/uk-plans-millions-of-coronavirus-antibody-tests-after-trial-success-report

a "game changer", or is it rather irrelevant except as a source of data about the spread of the disease, since you can get re-infected?


 
Posted : 18/07/2020 9:23 pm
Posts: 5820
Full Member
 

Feels like they are grasping for things to get good headlines.
Am sure the data will be interesting and maybe will give more info on asymptomatic rates. But like you I can't really see what it will achieve unless they want to give those with antibodies some sort of green pass to go out and spend money?


 
Posted : 18/07/2020 10:47 pm
Posts: 34479
Full Member
 

Id be very interested to see the details of the antibody test

Anecdotally, medic colleagues are complaining that the one being used to test NHS staff has required more than one go to show a positive when they're pretty certain they've had it and also problems with tests being lost


 
Posted : 18/07/2020 10:55 pm
Posts: 17326
Full Member
 

There are several methods to look for antibodies. The gold standard is an ELISA test. Enzyme linked imunosorbant assay. This needs some nice science to capture the little antibodies with some antigen, then bind another agent to them to report the detection. Abbot and Roche are the players here and have adapted their automated systems to measure anti-SARS-CoV2 spike protein antibodies. But you need a good blood sample and a big lab. They are very sensitive (accurate) so if you have antibodies, they’ll find them (99% of the time)

The second test that made all the news is the lateral flow test you can do at home with a sort of dipstick. These need a prick of blood And reporting reagent, but were very poor sensitivity (detecting about 75% of the time)

The game changer is that this new assay has the ease of lateral flow - do it at home, and the sensitivity of ELISA - get the right answer!

But we don’t yet understand what being antibody positive means, so it’s all rather moot! We will at least see with more clarity who has had exposure to the virus. But it does not measure titre (amount of antibodies) - that’s a whole new ballgame.

[tl:dr] the new antibody test will give you lab accuracy, done at home. If you’ve had it, you’ll know. It won’t tell you you’re immune, but it will tell you you’ve been vaccinated.


 
Posted : 19/07/2020 1:08 am
Posts: 6985
Free Member
 

cheers TiRed.

as an aside if TiRed says something that i thought when i read an article is it confirmation bias......


 
Posted : 19/07/2020 11:15 am
Posts: 8469
Full Member
 

Do we have any front line doctors on here?

Has our treatment of Covid patients increased markedly since the start? Am I more likely to survive a full blown visit to ITU than before?

As a reasonably fit 45 y/o white male, regularly tested and assessed for heart conditions, and O+ blood group I'm aware that Im not a major risk, but as I go back to work flying it would be nice to know if things are improving?


 
Posted : 19/07/2020 11:41 am
Posts: 0
Free Member
 

This is interesting. It is speculative but nobody else is setting out possible scenarios.
https://www.theguardian.com/society/2020/jul/19/what-happens-when-flu-meets-covid-19


 
Posted : 19/07/2020 12:30 pm
Posts: 34479
Full Member
 

I thought the PHE study only found ~ 90% accuracy in the serology tests?


 
Posted : 19/07/2020 12:31 pm
Posts: 2003
Full Member
 

[tl:dr] the new antibody test will give you lab accuracy, done at home. If you’ve had it, you’ll know. It won’t tell you you’re immune, but it will tell you you’ve been vaccinated.

Will this sort out the issue where it seems long haulers are returning negative antibody tests?

On the covid meets flu thing - qualifying with I've returned negative antibody test - I picked up what felt like a cold the end of June. It triggered some of the symptoms from March / April suspected Covid. All we do see to know is Covid wallops anyone with an underlying condition - no reason why this couldn't also include cold / flu.


 
Posted : 19/07/2020 12:47 pm
Posts: 10944
Full Member
 

Has our treatment of Covid patients increased markedly since the start? Am I more likely to survive a full blown visit to ITU than before?

My SiL went back to the NHS and has been working on Covid wards - her take at the moment is that they've got fewer patients so have more time for each one, and that is generally giving better outcomes. I get the impression that wouldn't be sustained if every bed is full and they're run ragged. Obvious caveat that there have been steps in treatment as well, but she's not convinced that's the sole factor.


 
Posted : 19/07/2020 12:55 pm
Posts: 17326
Full Member
 

I thought the PHE study only found ~ 90% accuracy in the serology tests?

Early lateral flow were much lower, automated ELISA well over 90%. The blood transfusion service serology may well have been 90%. But the new lateral flow looks promising.

Of course the LEVEL of antibodies is what matters and is overlooked by one and all. The limit of detection may or may not have relevance to protection levels.

Our anti-drug antibody tests can be so sensitive that they tell you you’ve had the drug. The detection limit is presets of magnitude below the therapeutic levels.


 
Posted : 19/07/2020 1:03 pm
Page 180 / 499