My first job was 45 miles from where I was living (with my parents at the time). It took an hour on a good day. Often it would take an hour and a half to get home.
Even at the age of 21, with no family of my own, no cooking, cleaning, etc I found it impossibly wearing. I'd get home for 7pm, eat, watch tv a bit, get on the net, wind down as much as I could (and wasn't ready to go to bed until about midnight). On a friday I'd get home and just pass out by 9pm and not wake up until mid day on saturday. I spent the weekend doing my laundry and getting ready for the next week, then back into it. I was laid off after 6 months, which almost came as a relief.
Now I have a commute that is 25-45 minutes. On the way home the last 7 miles are country roads over the pennines and there's two large hills between me and work. I am MUCH happier.
Seriously, don't do it. A friend of mine has done the weekly commute thing (working in derby, living in cambs) and he missed his family terribly. Quality of life is a combination of many things, but I think that no matter how good the job, you'll be paying too high a price in terms of driving stress, missing your kids (they'll be asleep when you get up and go, and they'll be in bed when you get home) and just not having any time for yourself.