It is a good bit of kit but the user interface could be better…
1. It can handle multiple bikes. Go menu, settings (spanner), bike settings, bike profiles, and set up each bike there. You can switch between them by pressing the power button briefly, clicking the bike name and choosing another. It’s a bit annoying it doesn’t recognise it automatically but seeing zero cadence usually reminds me to change if I forget.
2. Yes, I did this once too and have never used the option to navigate to the start since. If you answer no, it will pick up the route when you start it and will handle diversions etc during a planned route too, works pretty well although you might want to disable off course warnings because they’re pretty annoying too!
Good luck. 🙂