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Most folk I speak with about when they’re getting a vaccine understand the underlying principles…
Get yourself over to Twitter!!😮
On a personal note I'll benefit from this as I'm in my 40s and not a key worker. I don't however agree that some key workers shouldn't have been prioritised, but then again they kicked me out of group 6 and I didn't agree with that either.
How many 40- 50 year olds are there in the UK do we know?
How many 40- 50 year olds are there in the UK do we know?
About 8.5m
@Kelvin thanks. I don't do YouTube. Yet to view the recording but the talk is an hour, bit of a first foray into the world of online video.
Who would have thought this time last year that we would be getting angry about getting a vaccine.
Thanks for posting that - one thing I, and many others seem to have suffered, in the pandemic, is a loss of perspective.
The experts have made a decision, time for us armchair experts to leave it and hope that they are correct.
quite a lot of clientville are a bit lax with the guidelines.
Some of that will be down to finances, the choice between a box of masks or feeding the kids tonight finances. The future for them will be COVID is a disease of the poor as they can't WFH and their workplaces have lots of people in close proximity.
Surely the extra work, fallout and arguing needed to sort by occupation & risk could mean that -everyone's- jab was delayed slightly compared to just working by age?
@Tired YouTube will get the most exposure, how about doing it in conjunction with an established fact based channel e.g. Medlife Crisis (Dr Rohin Frances) or Dr Hope's Sick Notes
As it's Covid related it'll be demonetised so you won't be giving a collaborator any extra money. Both channels have produced lots of good, fact based coverage over the last year from a medical point of view. Neither have covered it from your point of view.
I just got my text invite for my first jab! booked in for next week, one week before my 45th. I know Cambridgeshire are doing exceptionally with their vaccination program but I wasn't expecting it until the summer.
Great news.
I didn't realise it was so split between different regions. My mum turn 65 this week and hasn't been able to book one in Norfolk yet and my 95 year old gran only had hers last week. Yet I'm 40 miles away in Cambridgeshire and I mines next week. My wife is a social worker and has already been done, she also says that many teachers have also been done (not just did to age) because the way the authority has run things. I didn't know there was that much variation from what were told should be happening nationally.
My girlfriend has just booked her first shot for tomorrow morning. She is 33 no underlying issues, however she is a secondary carer for her dad. He has had his first jab too. Nice positive news.
But I'm starting to fret about what will happen at the end of March when schools go back. Seeing other places around Europe and the world having what seems like sharply rising cases is just not what I was hoping too see.
Text tonight and jab booked for 9th March, 44 Manchester! Surprised but happy, MIL who is in 60's North Manchester only getting hers next week. Looking forward to seeing my parents.
truth be told I wouldn't be surprise if some areas were doing it alphabetically.
JVT saying that already certain boroughs showing infection rates going the wrong way in this last week.
Seems to me too many people have read that 'this is all over', but can't wait a second longer.
On our lunch time rides this week we've seen many people out in the countryside having picnics, walking in large groups, driving to beauty spots which aren't local, very little distancing in most cases and no mask wearing (in the countryside).
Fingers crossed that this trend does not continue and we can rely on the majority to 'do the right thing'.
I'm absolutely certain it will go the wrong way. People outdoors around where I live has been busy for the last 10 months, some days it's like being in the Trafford Centre.
I'd be willing to bet the dates of this easing will change pretty soon.
So it’s busy outside where you live for the last 10 months but that clearly hasn’t had a bearing on numbers in or out of lockdown and their behaviours haven’t differed. Doesn’t make sense.
Stcolin, just keep at what you’re going come March, don’t worry about the schools, just stay away from families with kids in schools. You’ll be fine. We’ll all meet up and ride before you know it.
Anyone see Newsnight?
https://twitter.com/mcash/status/1364938061105225728?s=21
…because the way the authority has run things. I didn’t know there was that much variation…
In some areas the “flexibility” is being used to get teachers vaccinated ahead of others of the same age, ready for the doubling (around here, as half the kids are already in at many schools) of the pupils on site. Makes sense. Here in West Yorkshire some council areas have gone for it, and others have stuck to the national headline approach. The devil is in the detail, and that’s pretty flexible now we’re on the under 60s.
@kelvin - I watched that last night and thought that the bloke was an utter weasel. He's a General Melchett. The woman was a breath of fresh air.
Doctors "have lost their lives in some cases, we need a similar commitment from the teaching profession" - Wilshaw, ex head of Ofsted
What the actual ****.
"The dead hand of Ofsted" was a great soundbite
Seems to me too many people have read that ‘this is all over’, but can’t wait a second longer.
On our lunch time rides this week we’ve seen many people out in the countryside having picnics, walking in large groups, driving to beauty spots which aren’t local, very little distancing in most cases and no mask wearing (in the countryside).
I think there is a few different things going on - the weather is improving and people are getting back outside again. Not sure how much can actually be proven about the impact of weather but it will be playing a part. A lot of people will be emerging from hibernation. Staying close to home is going to 'local' places a lot busier. The number of people walking the village paths nr me has gone up several 100% but that's from there only being half a dozen of us.
This weekend there will be a lot of people meeting up outdoors but there is also very little (if any) evidence of transmission outdoors? It feels the virus is circulating much more widely than the same point in the unwinding process last year. The risks are likely be be people carrying on their day out indoors. I suspect most us us dont think day to day that the current dominant virus is more transmissible than last year.
The increase in recreation is all going on against a background of some good times are coming. Most of this seems to be the media - either directly through journalism or indirectly with a switch in advertising. The whole background noise in people's lives is promoting better times are coming this will be filtering into people's decision making - even if they aren't consciously making a choice. What seems to be missing is the big if... which is what JVT was alluding too.
It does feel like unwinding is going to be date driven. Whilst Boris isn't going full funtime at the moment I'm not convinced he will ever press pause because it's going to be unpopular.
The return mass overseas travel concerns me most. I'd be a lot happier if this wasn't on the cards for another year - just to give the rest of world a chance to catch up on vaccination.
Wilshaw, WTF!
I think he has spoken some sense in the past but he's missed the point here. That said - I kind of get it; the risk to teachers is relatively low and the benefit of kids back in schools and proper education is felt to be high and there is a balance.
But it's optional as a balance, we can take a judgement of one risk over another. We can also judge that 'in time' kids will get back to schools and to some extent / with some damage, things will return to 'normal'. And with vaccines that 'in time' is coming quite fast. If there was no end in sight and just that risk / benefit equation to balance it might be a more reasonable ask.
Whereas medics don't really have that choice; there's no kicking it down the road and catch up later. Just statistics and body bags.
I’m very much in the “don’t open too soon camp”. On the other side of it though, my youngest (13 yesterday) is showing signs of struggling.
He enjoys school, is bright & engaged. The lack of social contact is having more of an impact than I thought. The day before his birthday he had a big wobble. Not enjoying school. Not looking fwd to his birthday. Worried about not making friends at new school(been off since yr 7 at a big grammar and doesn’t live near his mates).
Up until last week I thought he was coping well. If he is struggling there will be a lot worse out there.
What the actual ****.
He enjoys school, is bright & engaged. The lack of social contact is having more of an impact than I thought.
My two were the same. Hated the bubbles and the distancing and masks indoors when they went back in September, but their mood transformed.
Tne problem was the potential spread to teachers (which didn't happen at either of their schools due to strict rules) and the knock on risk to parents/families if the kids catch and spread it. In theory, the risks of deaths is much lower now the over 60s and vulnerable will mostly be vaccinated by 8th March, but I'm not keen on the 1 in 10 risk of long Covid as I won't be vaccinated till April, and I'm a relatively old parent.
I am intensely relaxed about people enjoying some fresh air and decent weather, be it local or not, singly or in groups.
The disease just isn’t significantly spread in such situations, and it’s much better they do this than go round to each other’s houses or cram into shops.
The more people you see outside, the fewer are inside.
I agree.
Both my kids schools are testing the day before they return, then twice per week. After 1st week, 2 per week at home.
That added to masks in class should make a difference.
Still think teachers should get the jab.
I got crammed in a tent outside a pharmacy with 5/6 people in there to register to get the jab jabbed yesterday. Why? Bit queasy today.
Numbers game Bill. Case rate UK is around 100/100000 people so 1/1000 (your area my be higher or lower, this is an illustration)
999/1000 don't have it. And the likelihood in your tent is lower again because of those who have it, the major proportion are symptomatic or know via testing and are at home.
But, go with 999/1000 chance that each of those people individually is clear. You want all four clear, so (999/1000)^4
That's 99.6%, and that's before the odds further in your favour above, and before the likelihood of someone actually transmitting it.
TL:DR - vanishing low. Don't have nightmares.
no mask wearing (in the countryside).
Whaaaat, people aren't wearing masks outdoors? Heathens. How the hell the infection rate is decreasing is beyond me.
It feels the virus is circulating much more widely than the same point in the unwinding process last year.
We have zero way of comparing this lockdown infection rates and decrease to the first as the testing capabilities has vastly improved since, the only comparison is hospital admissions and deaths which is falling at what appears to be a greater rate due to the vaccine, treatments and experience.
This weekend there will be a lot of people meeting up outdoors but there is also very little (if any) evidence of transmission outdoors?
As has been quoted by Sage scientists time and time again, there is no evidence so far to show that outdoor gatherings even en-mass such as packed beaches which occurred last spring yet rates still decreased shows.
The increase in recreation is all going on against a background of some good times are coming.
People are fed up and are releasing that tension in the safest manner.
I got crammed in a tent outside a pharmacy with 5/6 people in there to register to get the jab jabbed yesterday. Why? Bit queasy today.
I'd really not worry, again you're outside unless it was an enclosed tent and you were in there for a long time (I doubt).
Numbers game Bill. Case rate UK is around 100/100000 people so 1/1000 (your area my be higher or lower, this is an illustration)
The case rate is a fair bit lower than the real rate and doesn’t account for all the people who don’t bother getting tested or are asymptomatic etc.
The latest figures from the ONS based on random testing suggest 1 in 145 have Covid in England so still a fairly high prevalence.
Larry_Lamb - I don't need sarcastic comments thank you.
In the pedestrian shopping area of our small town, most people are wearing masks. However at our local beauty spot there were lots and lots of people all crammed together and some not making any effort to pass with any distance. They've come out to the countryside to get some fresh air. I certainly wasn't expecting them to wear masks, however until many more people are vaccinated I really feel uncomfortable with this many people even outside brushing past and blocking up areas because they are stopping for a picnic or snack in large groups when we are STILL IN LOCKDOWN.
Boris has told a rail conference that he expects all the offic workers to go back to working in their offices once restrictions are lifted this summer! Somehow I very much doubt it. People have proven they can work from home well to their bosses and a lot of people have enjoyed the commuting cost and time savings, not to mention all those who have moved home to the countryside as they don't need to be within sensible commuting distance every day.
Is Boris right or has he completely misjudged the situation as usual?
Is Boris right or has he completely misjudged the situation as usual?
This smacks of people in buildings = cash in the coffers of property owners. There's probably a lot of people who have his ear (or those who influence him) that will take an income hit if home working makes city centre property less profitable. No doubt there will be a lot about impacts, benefits, how it enriches the life of the employees but it is ultimately about the money.
Boris has told a rail conference that he expects all the offic workers to go back to working in their offices once restrictions are lifted this summer!
Johnson telling people what they want to hear shocker!
I'm one of the very very few people getting on a train into London from Milton Keynes at the moment
It's insane, each train normally holds 1000+ people (there's one every 15mins in rush hour). 99.99% are commuters
Now there are maybe 50 people a train and a much reduced service
2 of my neighbours, who I used to see on train regularly has set up a home office and both won't be going back
Season ticket costs £6k a year, mine I get thru a work loan
I'm lab based and even I'm now doing 1day a week wfh
The future is flexible
Boris will be looking to try and get the London property market trending in the right direction, as it’s largely the only region that dropped in the last 12 months; not to mention the pubs, bars, cafes etc., needing local footfall.
This smacks of people in buildings = cash in the coffers of property owners
Commercial property investments are also part of most folk's retirement portfolios - so be very wary of thinking only the "property owners" will benefit from getting peeps back into the office.
"We can't change things for the better, it'd be too hard"
Same people: "We will expend limitless effort, money and even lives to put things back how they were"
Was the same after the financial crisis
“We can’t change things for the better, it’d be too hard”
Same people: “We will expend limitless effort, money and even lives to put things back how they were”
Was the same after the financial crisis
Worryingly accurate. As a species, I'm not sure how we've evolved as far as we have faced with that sort of self destructive attitude.
Is lockdown over.
Due to working all week i needed thing from wicks, halfords and screwfix pre ordered as much as i could in the hope it would be quick in and out. How wrong was i.
The small town centre was as busy as i've ever seen it the supermarkets were packed and people everywhere. Thankfully distance was kept in the ques and staffmin all shops were great.
I noticed a bit more traffic going past home but apart from going on site twice and the supermarket not really been any where else since christmas.
So is this typical of the whole country?
Supermarket is busy, I try to go at odd hours e.g. 9pm. Screwfix / Toolstation - I pick up in the evening, always pretty empty.
Lots of red kites though, and the squirrels refuse to socially distance. I'm lucky to live somewhere fairly rural.
Commercial property investments are also part of most folk’s retirement portfolios – so be very wary of thinking only the “property owners” will benefit from getting peeps back into the office.
Yes, sorry, it was an overly simplistic comment.
We are at the point of what do we do with city centres. Some of this just feels like the continuation of the change that has hit villages and then increasingly larger towns over the last forty years. We are just now at the point it's impacting on cities. Covid has just accelerated the change. There is nothing that protects the traditional office base working from change - maybe it goes the way of heavy industry. It could be we start seeing a renaissance in smaller towns as people move back out again.
Going straight back to before doesn't solve problems - there's still pollution, there's still quality of life, there's still over crowding on trains / congestion on the roads. London is already creaking. We are at the point where atleast one water company has proposals for piping water down from the N of England. At this point you really have to ask wouldn't it be better to change direction. Move the people to the resources.
As with a lot of people I don't think there will be complete abandonment of office working more a move to blended options. I did some work on a project in the early nineties looking at potential impacts of internet / web on working. There were some influential thinkers who felt the writing wall was traditional offices. Technology would set us free and people would be working across the UK. Strangely that hasn't happened, creaking rural broadband might have something to do with it.
As with a lot of people I don’t think there will be complete abandonment of office working more a move to blended options
"blended" is a phrase that keeps getting thrown around by the leadership team at my place. Given the choice I will be in the office 5 days a week. The way I see it my home is my home I want to leave work at work. City centres wont die like people predict they will just change businesses adapt.
There is no one size fits all. For me the current job - I'd work from home 2-3 days a week. My previous employer - definitely wouldn't have wanted to work from home. Being able to log out and go home was part of getting through the day - dealing with highly stressed and as a result in some cases highly abusive people wasn't something I'd want in my house.
Is Covid over? You'd think so from the tourists who've descended on a peaceful North Yorkshire town. Car parks overflowing at the moment.
Packed around here as well. Don’t sweat it… it’s Spring… just don’t sit in traffic moaning about traffic… especially on a sunny Sunday.
Much rather them outside than mixing indoors
Just seen that some Brazilian variant has been detected in Scotland after the people flew from Brazil, via Paris. So am I right in thinking you only have to quarentine if you come from certain countries direct, but if you fly in via one of the 'safe' countries then you don't have to?
I understood that the 3 cases were all isolating as per the quarantine regulations.
BBC reporting one person not found.
I'm off to the underground bunker for another month.
https://twitter.com/broadcastscot/status/1366084792656224259?s=19
Why the **** are folk arriving then allowed to travel within the UK?
This is what we face for the next year - more folk traveling, people desperate to visit for not always essential reasons, other countries and other variants.
I'm staying away from you all.
I mentioned it a few pages back but the whole farce of only having to go through the quarantine hotels if you come direct from certain countries leaves us wide open to people taking indirect routes to bypass staying in an expensive hotel for a few days when they get back. It should be all through the hotels and tested or nothing, the stupid middle ground just gives a false sense of security.
The small town centre was as busy as i’ve ever seen it
Not in our small town centre, like a ghost town, compared to a normal Saturday. Went past a garden centre yesterday, the car park was rammed, though most looked like they had been vaccinated a couple of months ago.
Rode with a mate today for only the second time this year. Headed out to a cafe that's popular with cyclists and has done takeaway coffee and cake whenever they've been allowed. 18 cyclists there when we were there, plus quite a few locals who had walked or driven. We'd properly pushed the boundaries of the definition of "local" going as far as we did today, but seeing what some mates are posting on Strava, we barely went anywhere
This is what we face for the next year – more folk traveling, people desperate to visit for not always essential reasons, other countries and other variants.
I totally understand people wanting to get away for a foreign break, I can't believe that so many want to take that risk this year.
If this does get out in Scotland… will the “UK” media point out that it wouldn’t have if English airports had the same measures in place that Scottish airports do? Or just shrugs and more “unforeseen” and “alas” Johnsonism hand waving?
Social media seems to full of anger aimed at anyone reporting this. People actively want to be kept in the dark, don’t they. Often it’s the same people who latch on to conspiracies about “what they don’t want us to know”. Contradictory. Depressing.
just don’t sit in traffic moaning about traffic
Certainly not on a bike forum.
I wasn’t being literal… more “I was out enjoying a Sunny Sunday… and to my surprise, so was half the country…”
We’d properly pushed the boundaries of the definition of “local” going as far as we did today, but seeing what some mates are posting on Strava, we barely went anywhere
Am I understanding correctly that you're being critical of the behaviour of others, right after admitting spending the day with somebody from another household? (I'm making the assumption that you don't live with your friend)
Am I understanding correctly that you’re being critical of the behaviour of others, right after admitting spending the day with somebody from another household? (I’m making the assumption that you don’t live with your friend)
You do know that you are allowed to exercise outdoors with a friend?
You do know that you are allowed to exercise outdoors with a friend?
No, I didn't. I stand corrected. Explains all the groups I've seen out riding... A cafe ride seems to be pushing the definition a bit though.
You are allowed to exercise with one other with some social distancing - which does make conversationa bit tricky, I'll admit. We rode to a cafe that is legally allowed to sell takeaway products, and we went round the corner and ate them roughly 2 metres apart, away from anyone else.
Yes, as the crow flies the cafe is 15 miles away, and we did a total of 40 miles, which was probably breaking the spirits of the stay local. But it was the best 3 hours of 2021 so far, I'll be honest, and it won't be happening again for a few weeks yet.
Fair enough. I find it interesting the perceptions we have of what others are doing and how we justify our own actions. From what I observe, compliance of 'the spirit of the rules' is pretty much zero. The spirit appears to be broken on a collective level. But then I don't observe a lot because I only leave the house to go shopping or ride my bike. I do do the occasional longer ride.
The small town centre was as busy as i’ve ever seen it
It was really quiet out and about today. No signs of anyone heading into the Lakes. Roads were really quiet all day. Only one or two motorbikes out for the first spring ride. Plenty of cyclists only pairs or solo. Plenty of people out for local walks.
From what I observe, compliance of ‘the spirit of the rules’ is pretty much zero. The spirit appears to be broken on a collective level.
And yet the rates, hospitalisations and deaths still keep on falling, even with more kids in schools this time round due to the increased number of supposed key workers.
We had all of this in spring time 2020 during that lockdown and nearing the end when we had the roadmap, "omg look at all these people out and about" "look at those packed beaches" "look at those honeypots absolutely rammed"
Same story different year.
People being out and about outside, even in groups poses very little risk.
Derbyshire Police posted on their Twitter feed that they were fining any visitors to Matlock Bath who were not local. To be fair, even I'd struggle to argue it was local, let alone trying to socially distance on the main drag
Is there a similar graph for the other countries of the UK?
https://twitter.com/mark_mclaughlin/status/1366050983516725251?s=20
I'm always ready for some good news.
From what I observe, compliance of ‘the spirit of the rules’ is pretty much zero. The spirit appears to be broken on a collective level.
Not what I'm observing.
Most people seem to be local and pretty respectful of it.
I'm splitting hairs when I hope some would walk or cycle a little further away.
Even traveling further, within our authority, and even allowing for much busier trails, folk are keeping out of each others faces.
Unless you're queuing for the local coffee take away, in which case all distancing is ignored..
Yes, as the crow flies the cafe is 15 miles away, and we did a total of 40 miles, which was probably breaking the spirits of the stay local.
If everybody in the country only went as far from their house as they could manage under their own steam we would be in a much better position.
If everybody in the country only went as far from their house as they could manage under their own steam we would be in a much better position.
Unless they happened to live in a city with very few open areas. Then everyone would be crowded together. That's the reason that there is some flexibility in travel options.
Jeez - we've been going over this for almost a year. What is it that some folk just can't understand?
If everybody in the country only went as far from their house as they could manage under their own steam we would be in a much better position.
Really? I can ride out of London and do a lovely 100k loop on my bike.
I don’t because I don’t have a car owner in my bubble to come and pick me up if there’s a crash/mechanical and it’s selfish to do so and expect an ambulance to deal with me. So loops of quiet (for London suburbs) it is for now.
Why the **** are folk arriving then allowed to travel within the UK?
Yeah that was my point. If you fly direct from Brazil I believe you go straight to hotel to do your quarentine.
If you fly from Brazil to Paris, then on to the UK you then do your quarentine at home, and have to get there first. It beggars belief that someone thought this should be allowed. I mean it can't be hard for someone at passport control to work out which county someone has come from, especially if it's in South America.
Some (all?) these confirmed cases of the Brazilian variant came in on passengers a few days before the quarantine was imposed I believe.
Is this now as simple as saying that it's a battle between the Kent variant and the Brazilian variant? With the SA a contender too?
Which is most contagious basically? One "out breeding" the other, out infecting anyway?
The other variants were always going to get in I think its fair to say. Trying to limit their shouted is still a battle worth fighting mind you.
Unfortunately that means relying on our t & t system.... Oh dear.
There are two mutations in the spike protein that are noteworthy. N501Y is the UK variant. This binds harder to the ACE2 receptor which might make the strain more contagious. The SA and Br strains have E484K which evades immunity - well the most immunogenic part. It also renders some antibodies resistant. Combinations of the two mutations have arisen in the uk already.
The terminology is original amino acid - location on genome - new amino acid. The uk strain is also missing a couple of amino acids at 69/70 location on the string of amino acids.
To be honest, this is evolutionary biology in action. We’d probably select for it anyway. Especially in patients who catch it whilst immune compromised.
I’m less concerned than many as some cross immunity is what matters. There is a lot of in vitro evidence of preservation of some protection. It’s not all doom and gloom. These are not the vaccine escape mutants you are looking for. They will come but it is vey early days.
Thanks TiRed.
These are not the vaccine escape mutants you are looking for
Is there any historical or laboratory "induced" information to give even a rough idea how long we are looking at before a truly worrying variant emerges?
I know that's impossibly vague to answer I'm sure and the whole world is the petri dish but are we likely talking a few years or potentially a few months do you think?
Is there any historical or laboratory “induced” information to give even a rough idea how long we are looking at before a truly worrying variant emerges?
I'm guessing a big factor there is how widely the virus is circulating in the community.
Our whole quarantine, track and trace, isolate policy has been a sack of shit from the beginning. For a supposedly technologically advanced nation....
Is there any historical or laboratory “induced” information to give even a rough idea how long we are looking at before a truly worrying variant emerges?
There are experiments that look at generating point mutations in expression systems to find likely escape mutatants. It's natural way of mapping where your shiny therapeutic antibody does and does not bind. Normally these are done in "pseudovirus" systems - expression systems of benign viruses with the genetic information that express spike protein on the surface.
Then it's a numbers game. Rate of mutation is quite low - this is not HIV there is some error correction, and of course the number of hosts. Sadly that last one is a bit big, so low mutation and lots of hosts, rather than high mutation and few hosts.
I suspect it will be more than a year before significant pandemic strains, as per influenza. What we are seeing is genetic plasticity. I saw a mapping last week of every point mutation on the spike protein surface that has been reported into the GISAID global database more than 50 times. Basically it's the entire surface of the spike. Fact is there is still binding and protection from morbidity. That is what I want to see.
The vaccine should be viewed as helmet, elbow and knee pads. You WILL fall off. The damage may be mitigated by some protection. Everyone will catch this eventually endemic new virus. Not everyone needs some protection - some falls are pretty mild. But some will. And as any cyclist knows, you can't always tell who is going to fall badly!
Plenty to read here if interested in the genetics
The vaccine should be viewed as helmet, elbow and knee pads. You WILL fall off. The damage may be mitigated by some protection. Everyone will catch this eventually endemic new virus. Not everyone needs some protection – some falls are pretty mild. But some will. And as any cyclist knows, you can’t always tell who is going to fall badly!
I'm loving this, you should pass that to JVT.
So, what is the real life worry? Is it going to become as deadly to the young like it was to the elderly (similar to the Spanish Flu)? Surely the virus will be constantly looking to target the weakest and at this point or in the near future that will be those who are not vaccinated?