I discovered the joys of slimed tubes by accident after much scepticism. I bought a s/h bike for winter and rode the whole of the first winter without a puncture which, given the amount of gorse hawthorn and blackthorn around here, I thought was a miracle. I only discovered the previous owner had fitted slimed tubes when changing the tyres for the spring. I have two Cove Stiffee hardtails, one being a lighter build with UST tyres, the winterbike being a heavier build and riding both the extra weight of the tubes with both bikes on fat tyres is not especially noticeable most of the time.
The only mistake I ever made was not understanding that as they work, they will loose small amounts of air so when you start detecting those odd rocks through your rim that you did not feel earlier in the ride, you need stop soon to pump them up, I failed to and got a snake bite on a not particularly large rock which I am putting down to the low pressure resulting from the continual air loss each time a puncture was sealed.
Like all good things that come to the end when the tube started puncturing a lot, indicating the goo had dried or been used up. Given that I now have a bike that when ever I walk up to it the tyres are not flat, I put in new lightweight tubes and then filled anti puncture sealant. If they require any extra work to ride I would rather get fitter / put up with it than have to endure the fag of changing tubes on a wet winter ride.
If you have 1 bike and it's been on the full course at Weight Watchers for XC racing I'd think twice about doing it unless you have a spare general abuse wheel set, if you have a bike and are prone to adding lights mudguards bags and not fussed about the weight of your tyres or rims and hate punctures I would suggest you might want to consider it every winter at least it if your rims will take car valves. Am interested in Turnerfan's suggestion about presta tubes.