I wear wicking underwear etc, but are there any other options or remedies to use?
Wicking underwear that work perhaps?
I swear by X-Bionics energizer pants, ive done many 30-50mile runs in these. Not cheap, but mine have proved very durable. Although Ive just realised I have £150's worth of them. One for almost every day of the week. Dead comfy, no chaffing for me.
I'll also use some compression pants kit. Under Armour and Nike, if its going to be apocalyptically wet I use these. Not so comfy, but very very effective and preventing chaffing IME.
Never ever used chamois cream when on foot, no idea what the results would be. However, Ive known several runners/walkers resort to Vaseline as a solution. I've tried it, and found it to be a remedy and not a cure.