Just thought I’d add my experiences, I have a Squeezebox set-up which consists of a Touch, a Classic, a Radio and 3 Booms.
I run the Squeezebox server on a QNAP 4 Bay NAS which is based on a dual core Intel Atom chip.
I have all my music ripped to FLAC and stream it wireless to most of the players.
I can’t really fault the setup, the NAS makes a massive difference as I have run the server on lower spec NAS devices and it did struggle at times.
The QNAP has easy to install software “packages” and the Squeezebox server is available as one, so installation is as simple as a couple of mouse clicks.
I’ve played different songs on each player or even sync’d them all together (a simple menu option) and had them all playing the same songs around the house, and in the garden!
As has been mentioned some people are put off by the Squeezebox set-up because it can seem a bit complicated as it is so customisable.
I love my set-up and wouldn’t change it for anything else.