My girlfriend really really suffered on her saddle that came with her Giant Avail so we tried a specialised xc men’s saddle off a friend but same problem, then we tried a fizik gobi which rubbed the skin of her tailbone!
Eventually we went to the specialised concept store and had her ass measured and got a women’s specific road saddle and it is amazing according to her, no pain at all, it has a massive cut out down the middle and at the back, it was £80 though!
Shorts wise she uses altura padded shorts!