I like Safari and Chrome. Chrome reports back your browsing habits though. There's a way to disable this – just Google it.
Have to use IE at work for certain applications.
Firefox is ok but it's become bloated in recent years and looks pretty clunky IMHO. However the plugins and scripts that are available are very good. Some of the Greasemonkey scripts are invaluable.
Try them all and see how you get on. There's plenty of others out there too. As long as it's not IE 6!