I’m 5’10” and ride a 19″ next-gen with a 35mm stem and 800mm bars. It’s definitely bigger than the 17″ first-gen it replaced but I feel it’s a difference for the better.
I mainly use 650+ at the moment and yes the BB is a little lower but I’m not forever striking the peddles off rocks or other trail obstacles.
If you are swapping between boost and non-boost wheel sets you will need to change the rear swap-outs, not a hard job but I know it’s something that I wouldn’t be bothered to do before a ride. And as said you will need boost (110×15) fork for the front so would need boost adaptors for you non-boost front wheel.