TBH I think if you looked at the amount of anti-inflammatories pro’s take pretty regularly you might be surprised. Ibuprofen and other NSAIDs definitely reduce renal blood flow but it shouldn’t be significant for young healthy people. I would caution doing exercise with any pain that isn’t helped significantly by paracetamol/ibuprofen as they are very effective painkillers and anything that doesn’t pretty much go away after half an hour shouldn’t be ignored.
I wanted to ask how much gym and weights work people are doing? I have bought a cage, barbell and other associated equipment and now trying to religiously stick to one gym session a week. I use the fit4racing program which is pretty hardcore but I feel gives you enough bang for your buck you can just cycle or turbo the rest of the time. I’m not sure increasing the frequency would give me enough benefit.