The downtube will have extra metal near the holes.
Large maufacturer in properly designed bike shocker!!!
Large manufacturer in over-designed, over weight bike for skill-less riders non-shocker.
PP, I sugesst before you rubbish engineering principles you read up on them and then take a look at ways around the problem (which there are, as mentioned above) and then weigh up your priorities (cost, function, weight, special tube profiles etc…) when designing a frame.
SSP