I've got Fedora on my Laptop, Ubuntu netbook edition on my netbook, both dual boots. The odd bit of hardware isn't supported (e.g. winmodems) but everything else including works fine. The wireless on my netbook didn't work until I'd installed all the updates- so if it's a recent model you might want to have a wired ethernet connection on standby.
Haven't used any 3G cards, only 3G USB modems, both the ones I've tried worked fine.
What distro do you use at work? If it's not something niche I'd go along with that since you'll be more familiar with it if there's any problems.