Of those three I’d take the Supersix.
– The Hollowgram SI crankset is a belter, much lighter and stiffer than Ultegra and won’t look silly with any aftermarket rings you might put on it. There’s a reason they’re nearly triple the cost of Ultegra off the shelf.
– The wheelset, on paper at least looks superior. 1550g vs 1650 on the Genesis and 1900(!) on the Giant. Happy to be corrected on this. I haven’t ridden the FSAs.
Granted it’s marginally the least attractive (looks better in the flesh) of the three, and has a SRAM group which isn’t my personal preference but you get used to these things.