The first couple of rides, your left thumb will occasionally wave around where the front shifter used to be, then you’ll push your rear shifter again, just to be sure you don’t have a gear left, then you just get on with it and it’s fine. After the first couple of rides you don’t ever notice other than you are slightly quicker up hills than you were. It never actually gets to be a problem. Whether the advantages are enough that you’d prefer it overall, only you can tell, and even then, only after trying it for a bit.