Ok, my 2p worth.
I have been running X01 on my full bouncer for about 10 months now. I changed the chain out at 600 miles and did that again with the second one. So i now have 3 chains in rotation. When i change to a new chain there is considerable suck as the front chainring seems to not not want to let it go but that only lasts for 1 ride then its smooth operating as usual.
My 11 speed does not like muck, the tolerances are too tight with the NW chainring and the jockey wheels. Thats the only time i have issues with my shifting though. Also there is a horrible grinding noise when there is muck involved.
I run a 32 front ring as that gives me a good climbing vs normal running ratios. I very rarely use my 42 cog as i treat it as a get out of jail gear.
I am a bit anal about keeping it clean though. When you pay so much for that type of kit then 10 minutes after every ride is well spent cleaningthe drivetrain. So far it seems to be working for me. No abnormal wear and tear. And i have never dropped a chain yet 🙂