to echo some of the above, fit the biggest tyres you can in the frame, the comfort benefits going up from a standard 33mm CX tyre to a 40mm if it will fit are immense and worthwhile
even so it’s worthwhile mincing a bit on the descents, the time wasted in being a bit slower are more than made up for by not spending time mending punctures
you can do it on standard CX gearing but it will hurt, the climbs are heavily weighted towards the back half
i’ve tried tubeless many times on the CX on the South Downs and really suffered with sidewall flint gashes so run tubes now, others have better tales
my top tip is just to keep moving, it doesn’t have to be fast, just keep moving, stopping at gates (there are 100 or so) to look at the view, stopping for food and a pub lunch really chews your time
here’s a thing i wrote for road.cc on doing the Wiggle SDW in a day on the CX last year – The Way Of The Cross