The east part of that loop should be fine but the Hope/Edale side is a bit shit IMO – you have to slog up the broken road to Rushup Edge and Chapel gate, which aint worth the effort. The climb to Rushup will likely be wet, muddy, and rutty, and Rushup itself is a bit meh. Chapel gate is a waste of a descent, absolutely nothing interesting on it. If using that route I’d go straight on to Hope Cross at the point where it turns to go down the Roman road, then you could do some loops taking in Spud alley, Beast, and Hagg farm if you want to extend.
Oh, and keep an eye on koftheP on Twitter – should be useful for condition updates.