Just ordered an Osprey Momentum as I’ve started to carry my laptop a bit more and the old rucksack’s getting a bit long in the tooth. It has a dedicated laptop space which is held away from the back so looks a bit more comfy. I too am not that keen on panniers, and commute on the road bike most of the time.
Even though I hot desk, I seem to find somewhere to stash a few bits – shoes and towel as a minimum, and laptop if in the office on consecutive days.