Never understood why the perfect chainline is right in the middle of the cluster, it’s not like the cogs are the same size.
No, but the distance between the top of the chainring and the top of the sprocket is pretty much the same in all gears, so the distance over which the chain is being deflected is the same.
As reggiegasket says, the “standard” chainline is someone off centre. On 11 speed it actually lines up with 8th gear rather than 6th. Shifting is improved if you get it closer to centre, but depends on chainstay clearance and also the possibility of the chain catching on 10th gear when in 11th.