By their nature turbo trainers are “road biased” so unless you are used to long periods riding in the saddle they may take a bit of getting used to. Even with a lot of road miles in my legs I find it still takes a week or two to sort things out. Also your bike that “fits” might not actually do so.
This is good advice, I jumped in at the deep end and started trying to do sweetspot sessions (long, medium hard efforts) and then interval sessions (lots of short, very hard efforts).
I quickly spannered my knees which meant taking time off. I spoke with a coach and he was basically saying well d’uh, you can’t go from zero to 30 minutes of intervals without hurting something, so suggested starting with just one set of intervals, then building up every week, or doing a shorter sweet spot session but adding some intervals at the end. I had started by trying to do 3 sets of 10x40s intervals, and was hurting by the third set…
Turbos can be hard on knees depending on the model, the cheap turbo I used had a small flywheel which meant no inertia, so every pedal stroke is speeding the flywheel back up which is un-natural and can hurt the knees. Better trainers are smoother and more natural.
TL:DR? Start easy and build up.