Not a plumber but I believe some systems are basically a loop with rads plumbed off in parallel. But the system we have here has a sink rad for the boiler and a rad that should never be closed on the heating (we have a convection DHW system that always heats the single bathroom rad while doing the water and then the CH is driven by a pump off the DHW)
If you don’t have any way to maintain the loop it is bad for your boiler and pump.
If you have a thermostat and a TRV and the TRV is set lower than the thermostat then the boiler then the TRV can shut off before the thermostat so the boiler keeps running which is bad.
Thus you shouldnt have a TRV on the rad in the room where the thermostat is. If you have a moveable thermostat then you can fit TRVs but remember to fully open the one where the thermostat is or you can just unscrew the top bit and put a blanking cap over the top.