I still use an original Peavey ValveKing VK112 with an upgraded speaker. It sounds pretty darn good at gig volume but can need the volume to be high to get that sound – pedals are your friend.
I went down the rabbit hole of multi effects (like the built in ones on recent amps) but just found myself playing a lick, changing the sound, playing it again and again for ages and not actually making any music. In the end I settled on an overdrive (Boss Od-1 – great value and makes a Telecaster sound sublime), booster, bit of chorus, bit of delay and maybe a compressor and get on and play. Hmmm, still quite a lot of effects.
Anyway, I’s say go for a proper valve amp with not too many frills and buy a multi effects board if you want (and a Boss 0d-1 pedal as it’s brilliant). Always wanted a Peavey classic 30 and there’s plenty out there second hand. Just my view – it’s all good and the amount of tech available for reasonable outlay now is amazing. But, the best guitarists I’ve heard nearly always seem to have simple setups, but I’m not one of them.