I’ve run 2.2 and (far more often) 2.35 Maxxis mainly ikons but also ardent, 2.5 minions and a 3” chronicle on a pair of LB 35mm rims.
Strava data tells me over 25,000km on those wheels. Maxxis seem to size up big and the 2.35 are spot on. I thought they were ok but not quite wide enough for the 3” tyre. It was quite lightbulb shaped on there.
edit to add that a 2.35 on those rims seemed to me to hit a sweet spot. Really quite a lot of volume but with out the weight penalty of full plus’s sized wheels/tyres.
With the ikons I rode a lot of ultra distance stuff and covered ~10,000kn off road a year.