The 2.4 is a much heavier tyre than the 2.25, if that’s important to you. I was running 2.25s front and rear for about a year – they’re excellent, lots of grip for such a quick tyre. I’ve had 2.25s that weighed as little as 640g, but typically they’re about the quoted 660g. The 2.4 is quoted (I think) at another 200g – quite a weighty lump of rubber.
I bought a pair of 2.4s to go on my Trance when I was “beefing” it up so to speak. I couldn’t get the rear one in the frame when it was blown up. Putting it in flat then blowing it up leaves eff all clearance.
I am running a 2.4 front and 2.25 rear but even then the front one will “buzz” the neoprene fork guard thingy from time to time (on a set of Pikes) Not only is it a wide tyre it is very tall-much more so than the 2.25.
I wouldn’t buy them again for that reason only.