Tandmjeremy “personally I wouldn’t worry too much about the frame”
I could not disagree more… What cynic-al said is spot on. You have to get the frame for the job.
Take the surly cross check and long haul trucker. Almost identical bikes.
One is lovely when unloaded and twists itself with touring gear.
The other feels too solid when unloaded but has impeccable manners when fully loaded.
The transam is a very long ride with many many hours on the bike. I would want to get the right tool for the job. Also on big tours a selection of hand positions can prevent permanent injury (I know as I have made this mistake and I’m still suffering years later) If you use flats then stick bar ends and maybe ergo grips on.