You need to think about which way you hang them and how the reservoir is designed.
The Hope tech 2 eco lever for example, was a flip/flop design. The piston was to the rear of the lever with the reservoir out front. The Tech 3 by comparison, has the reservoir sat on top of the piston.
There will always be a little air caught under the flexible diaphragm under the cap but that doesn’t matter in normal use so long as the transfer port between the piston and reservoir remains submerged under the brake fluid.
If you hang a Tech 3 equipped bike by either the front or rear wheel, that transfer port which was at the bottom of the reservoir is now half way up. With a half decent bleed, not an issue.
With the Tech 2, it’s a slightly different story. The transfer port is half way up in normal use, it has to be because of the flip/flop design. Hang the bike by the front wheel and the transfer port is effectively at the bottom so no problem. Hang it by the back wheel and your port is now at the top so it only needs a little bit of air in the reservoir to be able to find its way into the piston bore and beyond.
Tying the lever back moves the piston and seals off the reservoir so it then doesn’t matter what you do.
The other consideration is what your fork oil does. It can be beneficial to hand them by the front wheel as its a chance to soak the top bushing.
Wow, that’s a lot in a phone!