1x here,, 40t chainriing and 11 speed 11/42 cassette. My Camino spends most of it’s time on the road, and on my road wheels it’s neatly 45kph before I spin out so there’s enough top end for me. In practice it just means I start coasting on the downhills sooner.
At the other end, I did end up pushing with luggage on some hills on the Second City Divide, but I suspect I would have on 2x too.
I’m happy with 1x for where I live and 90% of the riding I do, but that said if 2x GRX had been available at the time I would have got that instead.