I’ve got Candys or Eggbeaters on all of my bikes. I have had a couple fail when the outer bearing collapsed, but it wouldn’t have happened if I’d done even a little bit of maintenance. Both were fixed with the £16 service kit. So I’d say yes, it’s safe.
I don’t think I’ve ever maintained a M520/m540 pedal! Quick squirt with GT85 to stop the outer bits rusting, and a dribble of chain lube if I’m feeling generous. Crank Bros, I think I was getting 6 months between either servicing them or the pedal falling off the axle (this was the good/bad old days circa 2012)!
Shimano cleats also last many many many times longer than the brass ones on time, CB etc.