I’ve done a few, with no ensuing fiery death. Stay away by about 20mm from the weld areas – that might narrow your choice a bit.
I’d actually say 180 degrees from the front mech mount might not be great (this is based on uneducated experience drilling holes in unstayed dinghy masts, so YMMV – basically, you’ll have a potential weak point on both sides of a tube). I’d drill on the front left side of the seat tube looking at that pic, if it were my bike.
That said, pretty much every mtb these days has holes drilled all over the shop, albeit often with reinforcing pockets brazed or welded in. Remove stress risers and smooth edges and you should be good.