somewhat “how long is a piece of string” questions!!
I was very surprised at how strong you could make stuff though, when I got my 3d printer, so I wouldn’t rule it out!
As above (assuming you’re talking about hobbyist style FDM printing rather than the more industrial SLS process, which can be extremely strong but also very expensive!) if you print it so the layers are perpendicular to the expected forces that helps a lot. Lots of perimeters & top/bottom layers, as well as high infill, is key to strength – these are all properties you’d apply before printing rather than be specified in the design itself, so you’d have to be pretty explicit to whoever was printing it.
I’d definitely use a captive nut, etc rather than rely on 3d printed threads. Maybe post up a pic or sketch or something, there’s lots on here with 3d printing experience.