The heat exchanger in your boiler will be more efficient with the water at a lower temperature. Selecting a lower temperature will also mean the burner changes to the lower gas flow rate sooner, the lower flow rate being more efficient than the high flow rate. Lower water temperature also reduces temperature yo-yoing due to having very hot water in the radiators when the thermostat switches the boiler off.
I’ve now removed the central heating in my home but the last year I used it I found the lowest temperature possible, 33°C, resulted in the lowest gas consumption and the most regular house temperature.