Pretty much everything that’s been said but for me the biggest one that is always memorable is full hydraulic disk brakes.
I remember when V brakes came out they were awesome but they were still quite poor when the weather was foul and required setting up perfectly. The parallel arm things on XT+ were good but became sloppy very quickly.
When I first put a Hope C2 brake on the front of my bike it was a revelation. Much more braking force in all weathers and a genuine amazement for 6 months or so until I got a frame that could accept a rear brake, where I soon became used to such power.
Tubeless is up there although not easily thought of as a game changer because not getting punctures doesn’t really make the riding better. Not sure I can feel much difference in riding as I am too fat to use really low pressures.
Di2 on road bikes is immense and I’d have it instantly if I had a desire for tarmac.