Ultimately, the house always wins. If it didn't, bookies / casinos / fruit machines wouldn't exist.
There's exceptions of course, our "professional gambler" here for instance, but they're very very much the minority. A guy I went to college with used to get his lunch money every day from a single credit in the quiz machine in the café we went to (turned out, his dad was involved in writing the software for it). But in the long game there's almost always only ever one winner.
I throw the occasional quid into a quiz machine, a lottery ticket or a sweepstake. I rarely win anything, but that's not really the point for me. The quiz machines are like video games where you pay to play, the lottery is a way of donating to charity, and work sweepstakes are about taking part in something, it's a bit of fun. I've played "high stakes poker" with friends, where if you're very lucky and clean up you might come away five quid up at the end of the night.
Unless you're very very good, and most people aren't (though many think they are), it's a mugs' game for anything other than the casual quid IMHO.