swiss01 - Member
similarly a 12- 24 window just isn't true tho, broadly speaking
I'd say that "broadly speaking" it's very true.
Granted there's some small protective effect of parvolex to an already damaged liver (and even a tiny bit of evidence that iv dosing might undo some NABQI binding) but after a typical one-shot o/d, even 24hr is pushing your luck for any significant prevention
Staggered big overdoses are different but even then as a general rule the time from the clinically significant portion of the overdose (ie often 2nd "dose", that pushes the total amount into danger areas) would effectively start the clock (and from then, arguably, the window is shorter since glutathione is already depleted)
Incremental overdoses like taking 4-6g daily for some time in error are very different but don't really fit within the "popular" meaning of overdose as used here