As an alternative consideration, accomodation in Manhattan can be horrendously expensive, so depending on budget and how you prefer to spend your cash, you might want to consider getting somewhere just over in Brooklyn where prices will tend to drop pretty sharp and there are some cool nice areas, though not as ‘happening’ as Lower East Sde . You’d want to stay close to Manhattan would not be far from Worth street.
Could allow you to save cash on hotel and spend the remainder on food, whilst still getting a nice room.
But if you want somewhere swanky and in a cool area LES seems a good shout.could make some restaurant suggestions if you say what sort if grub you like – used to live over there for a bit.