I reckon you can, especially if it’s an internally cabled frame
… as long as:
There areN’T fixed internal guides for the cable inners
There ARE holes between down tube and BB (biggish hole); seat tube and BB; BB and through chainstay to the dropout (it looks like this is correct from the canyon site pics)
On my oldish ultegra 6870, the cabling goes:
• From shifters (1 wire each), under tape and out to join junction-A which hangs under the stem.
• Single wire out from Junction-A, through downtube to junction-B (which is shoved into the bottom end of the down tube).
Junction-B has 3 output wires connecting to
• (internal) Battery which is in my seatpost (jammed in with some foam but with means to allow it to pull back out again – zipties in my case)
• Front mech (Di2 frames have a hole to allow the wire out; yours may need some drill-related bravery)
• Rear mech