Did it with my new wheels and tyres, pro ones on primes. Both designed with tubeless in mind.
I had to use an airshot to get them up, so slightly harder than most mtb tyres I’ve tried.
On the road.. Honestly can’t tell the difference running my 25 mm tyres at 85 psi compared to my old GP 4000s at 100psi. I certainly wouldn’t make a wheel/tyre choice in future based on tubeless compatability..
However I also would not try any home bodges with equipment that isn’t specifically tubeless ready. On mtbs at low speeds and pressures I’d take the risk, but on road on a 45 mph decent.. Not a chance