My question is what do you want to do with the bike?
I guess I’m lucky in that I have a selection to draw upon; in my current road stable I have two Ti frames and three CF frames.
One Ti is my old time trialling frame that I’ve had for 6 years and clocked all my PBs on.
T’other is an Enigma etape which is my winter ‘hack’. 22lbs with guards but so nice to ride on and it ain’t going to slowly dissolve, unlike my various retired 531 road frames.
If you’re only looking at one frame and want speed then I’d probably lean towards CF. If you’re after comfort and/or can run multiple bikes, then I’d definitely recommend Ti.
Can’t comment on Van Nick but as the owner of two Omega/Enigma frames, I’d suggest looking at Justin Burls. Nowt wrong with Enigma but Burls will do custom builds for less money and people I know who have one have been very impressed.