Got a recovery disc or partition? Backup your your data, re-install.
Otherwise
Add/Remove program, just uninstall everything you don’t use, hey at worst you just re-install the few bits you did 😉
No idea what Disc cleanup util your using but uninstall it and just use the “oldtimers TFC” (temp file cleaner), the most basic and unintrusive util I’ve seen to do this (used to recommend CCleaner, TFC is so much cleaner..) that works really well
Personnally I like to run a complete disc scan & a defrag but never seen a defragged machine run quicker..
Nukes suggestion about MSConfig is good but unless your quite computer literate, it maybe daunting. Again think about replacing your hdd with an SSD disc. Clone it from the old hdd, if you’ve no recovery/installation media
PS: You do have at least 4Gb of ram?