I use them. Can’t say I get any more punctures than normal with them. If there are they’re still only once every 1000miles or so. I once did a whole summer commuting with them and only got 3.
They do go down though. Not as bad as latex, but you do need to top them up every 48hours or so.
I’ve not tried tubeless, but it it heavier so the difference is purely down to rolling resistance. My fear is when a tubeless tyre doesn’t seal it’ll be full of thorns, so a tube is useless. On an MTB that’s not a problem as you’re rarely more than a couple of hours walk from the car, road bike could concievably be 2 days walk!