network control or signal boxes on the route would need be taken control of, to stop them throwing the points and diverting the train,into sidings or accross junctions,to derail it, if it was an electric train, they would just switch off the power and allow it to coast to a stop.
But there have been various unexplained accidents/collisions on the railways, where the driver was killed, and the controls where set, and no braking took place(names witheld to protect innocent people who died).
The driver could also isolate the AWS and the new signalling one, so red signals wouldnt require him to cancel the alarm, one train crashed because the AWS was isolated and another reached very high speed after the warning system was tampered with and isolated by a driver recently.
Any atempt to overspeed into a terminal station would probably triger SPAD alarms, and for the control centre to go into DIXCEL mode, eg running to the bog.