I’ve been running a Spicy shick shuttle and CCDbAir on my Zesty for two years now (for 160mm travel)
It took just a couple of rides to set up (from scratch as no one had fitted one to a zesty back then, so no “base” tune existed) and haven’t really touched it since!
It’s been to the alps twice, done North wales, inc Snowdon and Cadir Idris, been to the peaks, South Wales, Fod, Lakes, even the bad lands of Swinley 😉 and it just works.
The only change i make is to add or remove a bit of air pressure depending what i’m riding and how much kit in carrying or the terrain i’m riding. Never really touch the damping tbh, as once it’s set, it’s set.